{"id":10054,"date":"2025-07-10T14:01:32","date_gmt":"2025-07-10T11:01:32","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=10054"},"modified":"2026-04-20T18:53:39","modified_gmt":"2026-04-20T15:53:39","slug":"celiac-disease-is-something-that-requires-genetic-testing-and-it-is-necessary-to-conduct-it","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/celiac-disease-is-something-that-requires-genetic-testing-and-it-is-necessary-to-conduct-it\/","title":{"rendered":"Celiac disease: what is it, who needs genetic testing and why is it done?"},"content":{"rendered":"
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Celiac disease is a chronic disease of the small intestine caused by intolerance to gluten, a protein found in wheat, rye, and barley. In celiac disease, consumption of gluten-containing foods causes inflammation of the lining of the small intestine, which leads to damage to its villi, impaired absorption of nutrients, and the development of various complications.<\/p>\n

To prevent the progression of the disease and avoid serious consequences, it is important to conduct a comprehensive examination in a timely manner. Medilab Plus offers advanced genetic testing for celiac disease using the PCR method - you can learn more about the service on the website:
https:\/\/medilab.km.ua<\/a><\/p>\n

Information about preparation, registration, and consultations is available at the link:
https:\/\/medilab.km.ua\/analizy<\/a><\/p>\n

What is celiac disease and why is it dangerous?<\/h2>\n

Celiac disease is not just a food allergy, but a genetically determined autoimmune disease. When gluten is consumed, an immune reaction occurs in the body of a person with celiac disease, which leads to inflammation of the small intestine, atrophy of the villi, and impaired absorption of vitamins, minerals, and nutrients.<\/p>\n

This can cause a number of complications, including:<\/p>\n

    \n
  • \n

    chronic diarrhea<\/p>\n<\/li>\n

  • \n

    weight loss<\/p>\n<\/li>\n

  • \n

    iron deficiency anemia<\/p>\n<\/li>\n

  • \n

    osteoporosis<\/p>\n<\/li>\n

  • \n

    infertility<\/p>\n<\/li>\n

  • \n

    increased risk of developing malignant intestinal tumors<\/p>\n<\/li>\n<\/ul>\n

    Typical symptoms of celiac disease<\/h2>\n
    \n
    \n\n\n\n\n\n\n\n\n\n
    Main manifestations<\/th>\nPossible accompanying symptoms<\/th>\n<\/tr>\n<\/thead>\n
    Abdominal pain, flatulence<\/td>\nDermatitis<\/td>\n<\/tr>\n
    Chronic diarrhea<\/td>\nGeneral weakness<\/td>\n<\/tr>\n
    Nausea, vomiting<\/td>\nRapid fatigue<\/td>\n<\/tr>\n
    Weight loss or insufficient weight gain<\/td>\nStepatorrhoea (fat in stool)<\/td>\n<\/tr>\n
    Anemia<\/td>\nGrowth failure in children<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
    <\/div>\n<\/div>\n<\/div>\n<\/div>\n

    Comprehensive diagnosis of celiac disease includes:<\/h2>\n
      \n
    1. \n

      Endoscopy and biopsy of the small intestine<\/strong><\/p>\n<\/li>\n

    2. \n

      Serological study<\/strong> (determination of IgA and tissue transglutaminase antibody levels)<\/p>\n<\/li>\n

    3. \n

      Genetic testing for the presence of HLA-DQ2\/DQ8 markers<\/strong><\/p>\n<\/li>\n<\/ol>\n

      It is especially important to consider that genetic testing is not a diagnostic method for confirming celiac disease, but its negative result allows for a high probability of ruling out this disease.<\/p>\n

      What is the importance of genetic testing?<\/h2>\n

      Close 95% patients with celiac disease have one of the genotypes<\/strong>:<\/p>\n

        \n
      • \n

        HLA-DQ2.5 (DQA105\/DQB1<\/em>02)<\/strong><\/p>\n<\/li>\n

      • \n

        HLA-DQ2.2 (DQA102\/DQB1<\/em>02)<\/strong><\/p>\n<\/li>\n

      • \n

        HLA-DQ8 (DQB103:02\/DQA1<\/em>03)<\/strong><\/p>\n<\/li>\n<\/ul>\n

        Identifying these markers helps:<\/p>\n

          \n
        • \n

          confirm genetic predisposition<\/p>\n<\/li>\n

        • \n

          identify the risk group<\/p>\n<\/li>\n

        • \n

          predict the likelihood of developing celiac disease<\/p>\n<\/li>\n<\/ul>\n

          \n
          \n\n\n\n\n\n\n\n
          Haplotype<\/th>\nRisk of developing celiac disease<\/th>\n<\/tr>\n<\/thead>\n
          HLA-DQ2.5<\/td>\nHigh<\/td>\n<\/tr>\n
          HLA-DQ8<\/td>\nModerate<\/td>\n<\/tr>\n
          Lack of markers<\/td>\nLow (almost rules out celiac disease)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
          \n
          <\/div>\n<\/div>\n<\/div>\n<\/div>\n

          When is genetic testing necessary?<\/h2>\n
          \n
          \n\n\n\n\n\n\n\n\n\n
          Indication<\/th>\nWho is recommended?<\/th>\n<\/tr>\n<\/thead>\n
          Presence of symptoms of celiac disease<\/td>\nPatients with suspected disease<\/td>\n<\/tr>\n
          Familial predisposition<\/td>\nIndividuals with a family history of celiac disease<\/td>\n<\/tr>\n
          Unexplained digestive disorders<\/td>\nPatients with mild symptoms<\/td>\n<\/tr>\n
          Preparing for a biopsy<\/td>\nTo eliminate the need for invasive studies<\/td>\n<\/tr>\n
          Lack of effect of gluten-free diet<\/td>\nTo control the diagnosis<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
          \n
          <\/div>\n<\/div>\n<\/div>\n<\/div>\n

          When testing is particularly indicated<\/h2>\n
            \n
          • \n

            If symptoms persist despite a gluten-free diet<\/p>\n<\/li>\n

          • \n

            Before a small intestine biopsy (if celiac disease is suspected)<\/p>\n<\/li>\n

          • \n

            If first-degree relatives have a confirmed diagnosis<\/p>\n<\/li>\n

          • \n

            If celiac disease is suspected, but other tests do not confirm the diagnosis<\/p>\n<\/li>\n

          • \n

            In case of relapses or ineffectiveness of therapy<\/p>\n<\/li>\n<\/ul>\n

            What does a genetic test result show?<\/h2>\n
            \n
            \n\n\n\n\n\n\n
            Result<\/th>\nWhat does it mean?<\/th>\n<\/tr>\n<\/thead>\n
            HLA-DQ2\/DQ8 detected<\/td>\nThere is a genetic predisposition to celiac disease<\/td>\n<\/tr>\n
            Not detected<\/td>\nHigh probability of not having celiac disease<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
            \n
            <\/div>\n<\/div>\n<\/div>\n<\/div>\n

            The presence of genetic markers does not always mean the presence of the disease, but allows you to identify a risk group.<\/p>\n

            Genetic testing for celiac disease is a modern and safe method that allows:<\/p>\n

              \n
            • \n

              Identify hereditary predisposition<\/p>\n<\/li>\n

            • \n

              Rule out celiac disease in doubtful cases<\/p>\n<\/li>\n

            • \n

              Start prevention in risk groups on time<\/p>\n<\/li>\n

            • \n

              Avoid unnecessary invasive tests<\/p>\n<\/li>\n<\/ul>\n

              Medilab Plus offers modern advanced genetic testing using PCR with high accuracy and reliability of results.<\/p>","protected":false},"excerpt":{"rendered":"

              Celiac disease is a chronic disease of the small intestine caused by intolerance to gluten, a protein found in wheat, rye, and barley.<\/p>","protected":false},"author":97,"featured_media":10055,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\n\u0426\u0435\u043b\u0456\u0430\u043a\u0456\u044f \u0449\u043e \u0446\u0435 \u043a\u043e\u043c\u0443 \u043f\u043e\u0442\u0440\u0456\u0431\u043d\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0435 \u0442\u0435\u0441\u0442\u0443\u0432\u0430\u043d\u043d\u044f HLA DQ2 DQ8<\/title>\n<meta name=\"description\" content=\"\u0429\u043e \u0442\u0430\u043a\u0435 \u0446\u0435\u043b\u0456\u0430\u043a\u0456\u044f \u043a\u043e\u043c\u0443 \u043f\u043e\u0442\u0440\u0456\u0431\u043d\u0435 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