{"id":10054,"date":"2025-07-10T14:01:32","date_gmt":"2025-07-10T11:01:32","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=10054"},"modified":"2026-04-20T18:53:39","modified_gmt":"2026-04-20T15:53:39","slug":"celiac-disease-is-something-that-requires-genetic-testing-and-it-is-necessary-to-conduct-it","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/celiac-disease-is-something-that-requires-genetic-testing-and-it-is-necessary-to-conduct-it\/","title":{"rendered":"Celiac disease: what is it, who needs genetic testing and why is it done?"},"content":{"rendered":"<p data-start=\"197\" data-end=\"553\">Celiac disease is a chronic disease of the small intestine caused by intolerance to gluten, a protein found in wheat, rye, and barley. In celiac disease, consumption of gluten-containing foods causes inflammation of the lining of the small intestine, which leads to damage to its villi, impaired absorption of nutrients, and the development of various complications.<\/p>\n<p data-start=\"555\" data-end=\"827\">To prevent the progression of the disease and avoid serious consequences, it is important to conduct a comprehensive examination in a timely manner. Medilab Plus offers advanced genetic testing for celiac disease using the PCR method - you can learn more about the service on the website:<br data-start=\"801\" data-end=\"804\" \/><a class=\"\" href=\"https:\/\/medilab.km.ua\/en\/\" target=\"_new\" rel=\"noopener\" data-start=\"804\" data-end=\"825\">https:\/\/medilab.km.ua<\/a><\/p>\n<p data-start=\"829\" data-end=\"935\">Information about preparation, registration, and consultations is available at the link:<br data-start=\"901\" data-end=\"904\" \/><a class=\"cursor-pointer\" target=\"_new\" rel=\"noopener\" data-start=\"904\" data-end=\"933\">https:\/\/medilab.km.ua\/analizy<\/a><\/p>\n<h2 data-start=\"942\" data-end=\"986\">What is celiac disease and why is it dangerous?<\/h2>\n<p data-start=\"988\" data-end=\"1284\">Celiac disease is not easy <a class=\"wpil_keyword_link\" href=\"https:\/\/medilab.km.ua\/en\/harchova-alergiya-symptomy-diagnostika-ta-kontrol-stanu\/\"   title=\"Food allergy: symptoms, diagnosis and condition control\" data-wpil-keyword-link=\"linked\"  data-wpil-monitor-id=\"125\">food allergy<\/a>, but a genetically determined autoimmune disease. When gluten is consumed in the body of a person with celiac disease, an immune reaction occurs, which leads to inflammation of the small intestine, atrophy of the villi, and impaired absorption of vitamins, minerals, and nutrients.<\/p>\n<p data-start=\"1286\" data-end=\"1336\">This can cause a number of complications, including:<\/p>\n<ul data-start=\"1337\" data-end=\"1486\">\n<li data-start=\"1337\" data-end=\"1356\">\n<p data-start=\"1339\" data-end=\"1356\">chronic diarrhea<\/p>\n<\/li>\n<li data-start=\"1357\" data-end=\"1372\">\n<p data-start=\"1359\" data-end=\"1372\">weight loss<\/p>\n<\/li>\n<li data-start=\"1373\" data-end=\"1399\">\n<p data-start=\"1375\" data-end=\"1399\">iron deficiency anemia<\/p>\n<\/li>\n<li data-start=\"1400\" data-end=\"1414\">\n<p data-start=\"1402\" data-end=\"1414\">osteoporosis<\/p>\n<\/li>\n<li data-start=\"1415\" data-end=\"1428\">\n<p data-start=\"1417\" data-end=\"1428\">infertility<\/p>\n<\/li>\n<li data-start=\"1429\" data-end=\"1486\">\n<p data-start=\"1431\" data-end=\"1486\">increased risk of developing malignant intestinal tumors<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"1493\" data-end=\"1522\">Typical symptoms of celiac disease<\/h2>\n<div class=\"_tableContainer_80l1q_1\">\n<div class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"1524\" data-end=\"1846\">\n<thead data-start=\"1524\" data-end=\"1569\">\n<tr data-start=\"1524\" data-end=\"1569\">\n<th data-start=\"1524\" data-end=\"1541\" data-col-size=\"sm\">Main manifestations<\/th>\n<th data-start=\"1541\" data-end=\"1569\" data-col-size=\"sm\">Possible accompanying symptoms<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"1618\" data-end=\"1846\">\n<tr data-start=\"1618\" data-end=\"1657\">\n<td data-start=\"1618\" data-end=\"1645\" data-col-size=\"sm\">Abdominal pain, flatulence<\/td>\n<td data-col-size=\"sm\" data-start=\"1645\" data-end=\"1657\">Dermatitis<\/td>\n<\/tr>\n<tr data-start=\"1658\" data-end=\"1698\">\n<td data-start=\"1658\" data-end=\"1676\" data-col-size=\"sm\">Chronic diarrhea<\/td>\n<td data-col-size=\"sm\" data-start=\"1676\" data-end=\"1698\">General weakness<\/td>\n<\/tr>\n<tr data-start=\"1699\" data-end=\"1742\">\n<td data-start=\"1699\" data-end=\"1718\" data-col-size=\"sm\">Nausea, vomiting<\/td>\n<td data-col-size=\"sm\" data-start=\"1718\" data-end=\"1742\">Rapid fatigue<\/td>\n<\/tr>\n<tr data-start=\"1743\" data-end=\"1809\">\n<td data-start=\"1743\" data-end=\"1782\" data-col-size=\"sm\">Weight loss or insufficient weight gain<\/td>\n<td data-col-size=\"sm\" data-start=\"1782\" data-end=\"1809\">Stepatorrhoea (fat in stool)<\/td>\n<\/tr>\n<tr data-start=\"1810\" data-end=\"1846\">\n<td data-start=\"1810\" data-end=\"1819\" data-col-size=\"sm\">Anemia<\/td>\n<td data-col-size=\"sm\" data-start=\"1819\" data-end=\"1846\">Growth failure in children<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\">\n<div class=\"absolute end-0 flex items-end\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2 data-start=\"1853\" data-end=\"1897\">Comprehensive diagnosis of celiac disease includes:<\/h2>\n<ol data-start=\"1899\" data-end=\"2108\">\n<li data-start=\"1899\" data-end=\"1947\">\n<p data-start=\"1902\" data-end=\"1947\"><strong data-start=\"1902\" data-end=\"1945\">Endoscopy and biopsy of the small intestine<\/strong><\/p>\n<\/li>\n<li data-start=\"1948\" data-end=\"2044\">\n<p data-start=\"1951\" data-end=\"2044\"><strong data-start=\"1951\" data-end=\"1978\">Serological study<\/strong> (determination of IgA and tissue transglutaminase antibody levels)<\/p>\n<\/li>\n<li data-start=\"2045\" data-end=\"2108\">\n<p data-start=\"2048\" data-end=\"2108\"><strong data-start=\"2048\" data-end=\"2106\">Genetic testing for the presence of HLA-DQ2\/DQ8 markers<\/strong><\/p>\n<\/li>\n<\/ol>\n<p data-start=\"2110\" data-end=\"2308\">It is especially important to consider that genetic testing is not a diagnostic method for confirming celiac disease, but its negative result allows for a high probability of ruling out this disease.<\/p>\n<h2 data-start=\"2315\" data-end=\"2357\">What is the importance of genetic testing?<\/h2>\n<p data-start=\"2359\" data-end=\"2424\">Close <strong data-start=\"2367\" data-end=\"2421\">95% patients with celiac disease have one of the genotypes<\/strong>:<\/p>\n<ul data-start=\"2425\" data-end=\"2533\">\n<li data-start=\"2425\" data-end=\"2460\">\n<p data-start=\"2427\" data-end=\"2460\"><strong data-start=\"2427\" data-end=\"2458\">HLA-DQ2.5 (DQA1<em data-start=\"2444\" data-end=\"2453\">05\/DQB1<\/em>02)<\/strong><\/p>\n<\/li>\n<li data-start=\"2461\" data-end=\"2496\">\n<p data-start=\"2463\" data-end=\"2496\"><strong data-start=\"2463\" data-end=\"2494\">HLA-DQ2.2 (DQA1<em data-start=\"2480\" data-end=\"2489\">02\/DQB1<\/em>02)<\/strong><\/p>\n<\/li>\n<li data-start=\"2497\" data-end=\"2533\">\n<p data-start=\"2499\" data-end=\"2533\"><strong data-start=\"2499\" data-end=\"2531\">HLA-DQ8 (DQB1<em data-start=\"2514\" data-end=\"2526\">03:02\/DQA1<\/em>03)<\/strong><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2535\" data-end=\"2570\">Identifying these markers helps:<\/p>\n<ul data-start=\"2571\" data-end=\"2681\">\n<li data-start=\"2571\" data-end=\"2607\">\n<p data-start=\"2573\" data-end=\"2607\">confirm genetic predisposition<\/p>\n<\/li>\n<li data-start=\"2608\" data-end=\"2634\">\n<p data-start=\"2610\" data-end=\"2634\">identify the risk group<\/p>\n<\/li>\n<li data-start=\"2635\" data-end=\"2681\">\n<p data-start=\"2637\" data-end=\"2681\">predict the likelihood of developing celiac disease<\/p>\n<\/li>\n<\/ul>\n<div class=\"_tableContainer_80l1q_1\">\n<div class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"2683\" data-end=\"2868\">\n<thead data-start=\"2683\" data-end=\"2721\">\n<tr data-start=\"2683\" data-end=\"2721\">\n<th data-start=\"2683\" data-end=\"2694\" data-col-size=\"sm\">Haplotype<\/th>\n<th data-start=\"2694\" data-end=\"2721\" data-col-size=\"sm\">Risk of developing celiac disease<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"2761\" data-end=\"2868\">\n<tr data-start=\"2761\" data-end=\"2784\">\n<td data-start=\"2761\" data-end=\"2773\" data-col-size=\"sm\">HLA-DQ2.5<\/td>\n<td data-col-size=\"sm\" data-start=\"2773\" data-end=\"2784\">High<\/td>\n<\/tr>\n<tr data-start=\"2785\" data-end=\"2807\">\n<td data-start=\"2785\" data-end=\"2795\" data-col-size=\"sm\">HLA-DQ8<\/td>\n<td data-col-size=\"sm\" data-start=\"2795\" data-end=\"2807\">Moderate<\/td>\n<\/tr>\n<tr data-start=\"2808\" data-end=\"2868\">\n<td data-start=\"2808\" data-end=\"2831\" data-col-size=\"sm\">Lack of markers<\/td>\n<td data-col-size=\"sm\" data-start=\"2831\" data-end=\"2868\">Low (almost rules out celiac disease)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\">\n<div class=\"absolute end-0 flex items-end\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2 data-start=\"2875\" data-end=\"2925\">When is genetic testing necessary?<\/h2>\n<div class=\"_tableContainer_80l1q_1\">\n<div class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"2927\" data-end=\"3354\">\n<thead data-start=\"2927\" data-end=\"2961\">\n<tr data-start=\"2927\" data-end=\"2961\">\n<th data-start=\"2927\" data-end=\"2939\" data-col-size=\"md\">Indication<\/th>\n<th data-start=\"2939\" data-end=\"2961\" data-col-size=\"md\">Who is recommended?<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"2999\" data-end=\"3354\">\n<tr data-start=\"2999\" data-end=\"3071\">\n<td data-start=\"2999\" data-end=\"3030\" data-col-size=\"md\">Presence of symptoms of celiac disease<\/td>\n<td data-col-size=\"md\" data-start=\"3030\" data-end=\"3071\">Patients with suspected disease<\/td>\n<\/tr>\n<tr data-start=\"3072\" data-end=\"3132\">\n<td data-start=\"3072\" data-end=\"3093\" data-col-size=\"md\">Familial predisposition<\/td>\n<td data-col-size=\"md\" data-start=\"3093\" data-end=\"3132\">Individuals with a family history of celiac disease<\/td>\n<\/tr>\n<tr data-start=\"3133\" data-end=\"3206\">\n<td data-start=\"3133\" data-end=\"3167\" data-col-size=\"md\">Unexplained digestive disorders<\/td>\n<td data-col-size=\"md\" data-start=\"3167\" data-end=\"3206\">Patients with mild symptoms<\/td>\n<\/tr>\n<tr data-start=\"3207\" data-end=\"3283\">\n<td data-start=\"3207\" data-end=\"3231\" data-col-size=\"md\">Preparing for a biopsy<\/td>\n<td data-col-size=\"md\" data-start=\"3231\" data-end=\"3283\">To eliminate the need for invasive studies<\/td>\n<\/tr>\n<tr data-start=\"3284\" data-end=\"3354\">\n<td data-start=\"3284\" data-end=\"3329\" data-col-size=\"md\">Lack of effect of gluten-free diet<\/td>\n<td data-col-size=\"md\" data-start=\"3329\" data-end=\"3354\">To control the diagnosis<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\">\n<div class=\"absolute end-0 flex items-end\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<h2 data-start=\"3361\" data-end=\"3399\">When testing is particularly indicated<\/h2>\n<ul data-start=\"3401\" data-end=\"3710\">\n<li data-start=\"3401\" data-end=\"3463\">\n<p data-start=\"3403\" data-end=\"3463\">If symptoms persist despite a gluten-free diet<\/p>\n<\/li>\n<li data-start=\"3464\" data-end=\"3526\">\n<p data-start=\"3466\" data-end=\"3526\">Before a small intestine biopsy (if celiac disease is suspected)<\/p>\n<\/li>\n<li data-start=\"3527\" data-end=\"3591\">\n<p data-start=\"3529\" data-end=\"3591\">If first-degree relatives have a confirmed diagnosis<\/p>\n<\/li>\n<li data-start=\"3592\" data-end=\"3665\">\n<p data-start=\"3594\" data-end=\"3665\">If celiac disease is suspected, but other tests do not confirm the diagnosis<\/p>\n<\/li>\n<li data-start=\"3666\" data-end=\"3710\">\n<p data-start=\"3668\" data-end=\"3710\">In case of relapses or ineffectiveness of therapy<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"3717\" data-end=\"3756\">What does a genetic test result show?<\/h2>\n<div class=\"_tableContainer_80l1q_1\">\n<div class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"3758\" data-end=\"3932\">\n<thead data-start=\"3758\" data-end=\"3784\">\n<tr data-start=\"3758\" data-end=\"3784\">\n<th data-start=\"3758\" data-end=\"3770\" data-col-size=\"sm\">Result<\/th>\n<th data-start=\"3770\" data-end=\"3784\" data-col-size=\"sm\">What does it mean?<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"3813\" data-end=\"3932\">\n<tr data-start=\"3813\" data-end=\"3874\">\n<td data-start=\"3813\" data-end=\"3836\" data-col-size=\"sm\">HLA-DQ2\/DQ8 detected<\/td>\n<td data-col-size=\"sm\" data-start=\"3836\" data-end=\"3874\">\u0404 <a class=\"wpil_keyword_link\" href=\"https:\/\/medilab.km.ua\/en\/genetic-predisposition-as-a-hereditary-factor-affecting-the-risk-of-disease\/\"   title=\"Genetic predisposition: how heredity affects the risk of disease\" data-wpil-keyword-link=\"linked\"  data-wpil-monitor-id=\"124\">genetic predisposition<\/a> to celiac disease<\/td>\n<\/tr>\n<tr data-start=\"3875\" data-end=\"3932\">\n<td data-start=\"3875\" data-end=\"3889\" data-col-size=\"sm\">Not detected<\/td>\n<td data-start=\"3889\" data-end=\"3932\" data-col-size=\"sm\">High probability of not having celiac disease<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\">\n<div class=\"absolute end-0 flex items-end\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p data-start=\"3934\" data-end=\"4039\">The presence of genetic markers does not always mean the presence of the disease, but allows you to identify a risk group.<\/p>\n<p data-start=\"4061\" data-end=\"4141\">Genetic testing for celiac disease is a modern and safe method that allows:<\/p>\n<ul data-start=\"4142\" data-end=\"4307\">\n<li data-start=\"4142\" data-end=\"4173\">\n<p data-start=\"4144\" data-end=\"4173\">Identify hereditary predisposition<\/p>\n<\/li>\n<li data-start=\"4174\" data-end=\"4217\">\n<p data-start=\"4176\" data-end=\"4217\">Rule out celiac disease in doubtful cases<\/p>\n<\/li>\n<li data-start=\"4218\" data-end=\"4265\">\n<p data-start=\"4220\" data-end=\"4265\">Start prevention in risk groups on time<\/p>\n<\/li>\n<li data-start=\"4266\" data-end=\"4307\">\n<p data-start=\"4268\" data-end=\"4307\">Avoid unnecessary invasive tests<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"4309\" data-end=\"4432\">Medilab Plus offers modern advanced genetic testing using PCR with high accuracy and reliability of results.<\/p>","protected":false},"excerpt":{"rendered":"<p>Celiac disease is a chronic disease of the small intestine caused by intolerance to gluten, a protein found in wheat, rye, and barley.<\/p>","protected":false},"author":97,"featured_media":10055,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/10054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/97"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=10054"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/10054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/10055"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=10054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=10054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=10054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}