<\/div>\n<\/div>\n<\/div>\n<\/div>\n
When are tumor markers really needed?<\/strong><\/p>\nIt is not advisable to determine tumor markers for everyone at once. They are used:<\/p>\n
\n- \n
with questionable ultrasound findings<\/p>\n<\/li>\n
- \n
before or after surgery (to assess residual tumor)<\/p>\n<\/li>\n
- \n
in dynamics - for monitoring relapse<\/p>\n<\/li>\n
- \n
during targeted or immunotherapy - to assess response<\/p>\n<\/li>\n<\/ul>\n
Also, CA IX and VEGF testing can help in choosing a personalized treatment plan.<\/p>\n
Why is it important to consider dynamics, not just the result of a single analysis?<\/strong><\/p>\nThe level of tumor markers varies depending on the phase of the disease, the state of the immune system, and the presence of concomitant pathologies. Therefore, a one-time increase in the marker is not a sentence. However, a gradual increase, even within normal limits, is already a reason for caution.<\/p>\n
In what cases are tumor markers not informative?<\/strong><\/p>\nTumor markers do not replace instrumental methods - CT, MRI, ultrasound. They should not be used as screening without clinical indications. A low level of a marker does not guarantee the absence of a tumor, especially at an early stage or with slow growth of the neoplasm.<\/p>\n
Do tumor markers influence the choice of therapy?<\/strong><\/p>\nYes. For example, patients with high VEGF levels respond better to treatment with angiogenesis inhibitors (sunitinib, axitinib). And high CA IX expression is associated with a better prognosis with immunotherapy. Knowledge of the molecular profile of the tumor helps to choose an effective combination of drugs.<\/p>\n
Current trends: genetic markers and liquid biopsy<\/strong><\/p>\nThe scientific community is actively investigating circulating tumor DNA as a source of new tumor markers. This approach is called liquid biopsy<\/strong> and is already beginning to be used in large oncology centers.<\/p>\nAlso promising are:<\/p>\n
\n- \n
MicroRNAs (miRNAs) that alter gene expression in tumors<\/p>\n<\/li>\n
- \n
Metabolic profiles of blood plasma<\/p>\n<\/li>\n
- \n
Exosomes are vesicles containing proteins and tumor DNA.<\/p>\n<\/li>\n<\/ul>\n
Tumor markers for renal cell carcinoma are not a magic wand, but a powerful tool in the hands of an oncologist. They not only help to clarify the diagnosis, but also form the basis for individualized treatment. In combination with imaging and morphology, tumor markers open up a new level of accuracy and predictability in the diagnosis of kidney cancer. If you or your doctor suspects kidney pathology, do not delay the examination. Tumor markers can provide an important clue even before the disease declares itself in full voice.<\/p>","protected":false},"excerpt":{"rendered":"
Kidney cancer is one of the most insidious cancers, often developing asymptomatically. In most cases, it is discovered by chance \u2014<\/p>","protected":false},"author":627,"featured_media":10106,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,233],"tags":[],"class_list":["post-10105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zahvoryuvannya-ta-symptomy","category-rozshyfrovka-analiziv-ta-pidgotovka"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/10105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=10105"}],"version-history":[{"count":1,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/10105\/revisions"}],"predecessor-version":[{"id":14069,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/10105\/revisions\/14069"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/10106"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=10105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=10105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=10105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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