{"id":10288,"date":"2025-08-01T21:33:30","date_gmt":"2025-08-01T18:33:30","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=10288"},"modified":"2026-04-20T18:53:38","modified_gmt":"2026-04-20T15:53:38","slug":"thrombophilia-analysis-diagnosis-significance-and-prevention","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/thrombophilia-analysis-diagnosis-significance-and-prevention\/","title":{"rendered":"Thrombophilia test: diagnosis, significance and prevention"},"content":{"rendered":"
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Thrombophilia is a pathological condition in which the balance between the blood clotting and anticoagulation systems is disturbed in the body. As a result, the risk of blood clots forming increases, which can lead to dangerous complications: deep vein thrombosis, pulmonary embolism, stroke or heart attack. Often this disease is hereditary and manifests itself in young people, which makes thrombophilia test<\/a> an important prevention tool.<\/p>\n

Why does thrombophilia occur?<\/strong><\/h2>\n
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    Hereditary causes<\/strong>: mutation of the F5 gene (Leiden mutation<\/em>), mutation of the F2 gene (prothrombin, G20210A<\/em>), MTHFR gene variants that disrupt folic acid metabolism, PAI-1 mutations that affect blood clot dissolution.<\/p>\n<\/li>\n

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    Acquired factors<\/strong>: prolonged immobilization, taking oral contraceptives, pregnancy and the postpartum period, cancer, obesity, smoking, hypertension.<\/p>\n<\/li>\n<\/ol>\n

    When is a thrombophilia test prescribed?<\/strong><\/h2>\n