{"id":11171,"date":"2025-12-04T15:26:10","date_gmt":"2025-12-04T13:26:10","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=11171"},"modified":"2026-04-20T18:53:29","modified_gmt":"2026-04-20T15:53:29","slug":"microbiome-and-cardiovascular-disease-as-a-condition-of-the-intestine-affects-the-heart-and-blood-vessels","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/microbiome-and-cardiovascular-disease-as-a-condition-of-the-intestine-affects-the-heart-and-blood-vessels\/","title":{"rendered":"Microbiome and cardiovascular disease: how the state of the gut affects the heart and blood vessels"},"content":{"rendered":"
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Microbiome<\/a> \u2014 is a collection of microorganisms that inhabit the human body, primarily the intestines. In recent years, scientific research has proven that the microbiome plays an important role not only in digestion and immune defense, but also in the development of cardiovascular diseases. Disruption of the balance of intestinal microflora is associated with an increased risk of atherosclerosis, hypertension, and coronary heart disease.<\/p>\n

Cardiovascular disease remains one of the leading causes of death worldwide, and understanding the role of the microbiome opens up new opportunities for prevention and early diagnosis.<\/p>\n

What is the microbiome and why is it important?<\/h3>\n

The gut microbiome is made up of trillions of bacteria, viruses, and fungi that are involved in nutrient metabolism, vitamin synthesis, and immune response regulation. In a healthy state, the microbiome is in dynamic equilibrium, supporting normal body function.<\/p>\n

When the balance is disrupted (a condition known as dysbiosis), inflammation increases and fat and carbohydrate metabolism changes, which can negatively affect the heart and blood vessels.<\/p>\n

How the microbiome affects the cardiovascular system<\/h3>\n

The influence of the microbiome on cardiovascular disease is realized through several key mechanisms.<\/p>\n

Inflammation and immune response<\/h4>\n

A disrupted microbiome can stimulate chronic low-level inflammation. Inflammation is considered one of the main factors in the development of atherosclerosis and damage to the vascular wall. According to World Health Organization<\/span><\/span>, chronic inflammation significantly increases the risk of cardiovascular complications.<\/p>\n

Metabolites of intestinal bacteria<\/h4>\n

Some gut bacteria produce metabolites that directly affect the heart and blood vessels. The most well-known example is trimethylamine-N-oxide (TMAO). Elevated levels of this substance are associated with the development of atherosclerosis and thrombosis.<\/p>\n

Studies summarized by experts Mayo Clinic<\/span><\/span>, indicate that TMAO concentration in the blood may be an independent prognostic factor for cardiovascular events.<\/p>\n

Effect on lipid metabolism<\/h4>\n

The microbiome is involved in the regulation cholesterol level<\/a> and fatty acids. Dysbiosis can contribute to increased levels of \u00abbad\u00bb cholesterol<\/a> (LDL) and a decrease in "good" (HDL), which is directly related to the risk of atherosclerosis.<\/p>\n

\"gut-heart<\/h3>\n

Which cardiovascular diseases are linked to the microbiome?<\/h3>\n

Scientific evidence suggests a link between the microbiome and the following conditions:<\/p>\n