{"id":8796,"date":"2024-12-29T08:20:52","date_gmt":"2024-12-29T06:20:52","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=8796"},"modified":"2026-04-20T18:54:44","modified_gmt":"2026-04-20T15:54:44","slug":"molecular-diagnosis-of-alergij-novyj-riven-tochnosti-u-vyyavlenni-allergeniv","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/molecular-diagnosis-of-alergij-novyj-riven-tochnosti-u-vyyavlenni-allergeniv\/","title":{"rendered":"Molecular allergy diagnostics: a new level of accuracy in allergen detection"},"content":{"rendered":"<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-top\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;8796&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;top&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;1655&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;4.7&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;Rate this post&quot;,&quot;legend&quot;:&quot;4.7\\\/5 - (1655 votes)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0430\u043b\u0435\u0440\u0433\u0456\u0439: \u043d\u043e\u0432\u0438\u0439 \u0440\u0456\u0432\u0435\u043d\u044c \u0442\u043e\u0447\u043d\u043e\u0441\u0442\u0456 \u0443 \u0432\u0438\u044f\u0432\u043b\u0435\u043d\u043d\u0456 \u0430\u043b\u0435\u0440\u0433\u0435\u043d\u0456\u0432&quot;,&quot;width&quot;:&quot;133.8&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 133.8px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 19.2px;\">\n            4.7\/5 - (1655 votes)    <\/div>\n    <\/div>\n<p class=\"\" data-start=\"82\" data-end=\"579\">Allergy is a complex and multifactorial disease that can manifest itself in the form of skin rashes, swelling, runny nose, cough, shortness of breath or even anaphylaxis. Classic diagnostic methods - skin tests and determination <a href=\"https:\/\/medilab.km.ua\/en\/the-general-rule-is-that-the-cause-of-the-dyspnea-is-the-same-as-the-diagnostic-methods\/\">total IgE<\/a> \u2014 do not always allow us to accurately determine the cause of an allergic reaction. That is why modern allergology is increasingly using <strong data-start=\"440\" data-end=\"475\">molecular diagnostics of allergies<\/strong> \u2014 a highly accurate method that allows you to detect the body&#039;s reaction to specific protein components of allergens.<\/p>\n<h3 class=\"\" data-start=\"581\" data-end=\"622\"><strong>What is molecular allergy diagnostics?<\/strong><\/h3>\n<p class=\"\" data-start=\"624\" data-end=\"993\">Molecular allergy diagnostics (component-resolved diagnostics, CRD) is a laboratory analysis method that allows you to determine <strong data-start=\"750\" data-end=\"800\">sensitivity to individual allergen molecules<\/strong>, and not just their mixtures. For example, instead of simply determining whether you are allergic to birch pollen, you can find out which protein (Bet v 1, Bet v 2, etc.) the immune system is reacting to.<\/p>\n<p class=\"\" data-start=\"995\" data-end=\"1015\">This approach allows:<\/p>\n<ul data-start=\"1017\" data-end=\"1243\">\n<li class=\"\" data-start=\"1017\" data-end=\"1076\">\n<p class=\"\" data-start=\"1019\" data-end=\"1076\">avoid <strong data-start=\"1027\" data-end=\"1074\">false positive or cross-reaction results<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"1077\" data-end=\"1121\">\n<p class=\"\" data-start=\"1079\" data-end=\"1121\">to evaluate <strong data-start=\"1087\" data-end=\"1119\">severity of potential reaction<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"1122\" data-end=\"1186\">\n<p class=\"\" data-start=\"1124\" data-end=\"1186\">to choose more precisely <strong data-start=\"1142\" data-end=\"1184\">allergen-specific immunotherapy (ASIT)<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"1187\" data-end=\"1243\">\n<p class=\"\" data-start=\"1189\" data-end=\"1243\">to determine <strong data-start=\"1199\" data-end=\"1241\">risk of anaphylaxis with food allergies<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"1245\" data-end=\"1287\"><strong>Main advantages of molecular analysis<\/strong><\/h3>\n<div class=\"overflow-x-auto contain-inline-size\">\n<table data-start=\"1289\" data-end=\"1940\">\n<thead data-start=\"1289\" data-end=\"1381\">\n<tr data-start=\"1289\" data-end=\"1381\">\n<th data-start=\"1289\" data-end=\"1323\">Advantage<\/th>\n<th data-start=\"1323\" data-end=\"1381\">Importance for the patient<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"1475\" data-end=\"1940\">\n<tr data-start=\"1475\" data-end=\"1569\">\n<td>High specificity<\/td>\n<td>Tests not the general allergen, but individual proteins in its composition<\/td>\n<\/tr>\n<tr data-start=\"1570\" data-end=\"1661\">\n<td>Detection of cross-reactions<\/td>\n<td>Helps avoid mistakes in diet or treatment<\/td>\n<\/tr>\n<tr data-start=\"1662\" data-end=\"1753\">\n<td>Predicting the severity of a reaction<\/td>\n<td>Allows you to assess the risk of severe allergies<\/td>\n<\/tr>\n<tr data-start=\"1754\" data-end=\"1847\">\n<td>ASIT Optimization<\/td>\n<td>Allows you to exclude unnecessary components from therapy<\/td>\n<\/tr>\n<tr data-start=\"1848\" data-end=\"1940\">\n<td>Lifestyle recommendations<\/td>\n<td>Provides personalized information about safe products<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h3 data-start=\"1942\" data-end=\"1987\"><img decoding=\"async\" class=\"alignnone size-full wp-image-8798\" src=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19.jpg\" alt=\"Results of molecular allergy diagnostics with IgE markers\" width=\"1200\" height=\"675\" srcset=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19.jpg 1200w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19-150x84.jpg 150w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19-600x338.jpg 600w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19-300x169.jpg 300w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19-1024x576.jpg 1024w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/03\/medical-lab-worker-analyzing-blood-serum-conducting-virus-test-modern-equipped-lab-late-night-team-specialists-examining-vaccine-evolution-using-high-tech-treatment-against-covid19-768x432.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/h3>\n<h3 class=\"\" data-start=\"1942\" data-end=\"1987\"><strong>Who is recommended for molecular testing?<\/strong><\/h3>\n<ul data-start=\"1989\" data-end=\"2327\">\n<li class=\"\" data-start=\"1989\" data-end=\"2042\">\n<p class=\"\" data-start=\"1991\" data-end=\"2042\">Patients with <strong data-start=\"2004\" data-end=\"2040\">suspected polyvalent allergy<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"2043\" data-end=\"2098\">\n<p class=\"\" data-start=\"2045\" data-end=\"2098\">People from <strong data-start=\"2054\" data-end=\"2088\">severe or atypical manifestations<\/strong> allergies<\/p>\n<\/li>\n<li class=\"\" data-start=\"2099\" data-end=\"2157\">\n<p class=\"\" data-start=\"2101\" data-end=\"2157\">In preparation for <strong data-start=\"2119\" data-end=\"2155\">allergen-specific immunotherapy<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"2158\" data-end=\"2252\">\n<p class=\"\" data-start=\"2160\" data-end=\"2252\">In case <strong data-start=\"2167\" data-end=\"2219\">allergies to products containing cross-linked proteins<\/strong> (nuts, apples, seafood)<\/p>\n<\/li>\n<li class=\"\" data-start=\"2253\" data-end=\"2296\">\n<p class=\"\" data-start=\"2255\" data-end=\"2296\">Children with suspected <strong data-start=\"2275\" data-end=\"2294\">food allergy<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"2297\" data-end=\"2327\">\n<p class=\"\" data-start=\"2299\" data-end=\"2327\">At <strong data-start=\"2303\" data-end=\"2327\">history of anaphylaxis<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"2329\" data-end=\"2352\"><strong>How the analysis is done<\/strong><\/h3>\n<ul data-start=\"2354\" data-end=\"2681\">\n<li class=\"\" data-start=\"2354\" data-end=\"2384\">\n<p class=\"\" data-start=\"2356\" data-end=\"2384\"><strong data-start=\"2356\" data-end=\"2368\">Material<\/strong>: venous blood<\/p>\n<\/li>\n<li class=\"\" data-start=\"2385\" data-end=\"2497\">\n<p class=\"\" data-start=\"2387\" data-end=\"2497\"><strong data-start=\"2387\" data-end=\"2401\">Preparation<\/strong>: analysis is in progress <strong data-start=\"2422\" data-end=\"2456\">without the need to discontinue medication<\/strong>, on an empty stomach or after a light breakfast<\/p>\n<\/li>\n<li class=\"\" data-start=\"2498\" data-end=\"2563\">\n<p class=\"\" data-start=\"2500\" data-end=\"2563\"><strong data-start=\"2500\" data-end=\"2524\">Execution time<\/strong>: 3 to 10 days depending on the panel<\/p>\n<\/li>\n<li class=\"\" data-start=\"2564\" data-end=\"2681\">\n<p class=\"\" data-start=\"2566\" data-end=\"2681\"><strong data-start=\"2566\" data-end=\"2579\">Result<\/strong>: contains <strong data-start=\"2589\" data-end=\"2621\">list of allergen components<\/strong>, levels of specific IgE to each and their clinical significance<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"2683\" data-end=\"2718\"><strong>Examples of allergenic components<\/strong><\/h3>\n<div class=\"overflow-x-auto contain-inline-size\">\n<table data-start=\"2720\" data-end=\"3323\">\n<thead data-start=\"2720\" data-end=\"2779\">\n<tr data-start=\"2720\" data-end=\"2779\">\n<th data-start=\"2720\" data-end=\"2739\">Source of allergen<\/th>\n<th data-start=\"2739\" data-end=\"2758\">Basic molecules<\/th>\n<th data-start=\"2758\" data-end=\"2779\">Clinical significance<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"2841\" data-end=\"3323\">\n<tr data-start=\"2841\" data-end=\"2937\">\n<td>Birch<\/td>\n<td>Bet v 1, Bet v 2<\/td>\n<td>Bet v 1 is a major protein associated with severe allergies<\/td>\n<\/tr>\n<tr data-start=\"2938\" data-end=\"3033\">\n<td>Peanut<\/td>\n<td>Ara h 1, Ara h 2<\/td>\n<td>Ara h 2 is an indicator of high risk of anaphylaxis<\/td>\n<\/tr>\n<tr data-start=\"3034\" data-end=\"3129\">\n<td>Apple<\/td>\n<td>Mal d 1<\/td>\n<td>Associated with cross-allergy to birch pollen<\/td>\n<\/tr>\n<tr data-start=\"3130\" data-end=\"3226\">\n<td>Milk<\/td>\n<td>Bos d 8 (casein)<\/td>\n<td>Resistant to heat treatment, causes severe reactions<\/td>\n<\/tr>\n<tr data-start=\"3227\" data-end=\"3323\">\n<td>Cat<\/td>\n<td>Fel d 1, Fel d 4<\/td>\n<td>Fel d 1 is the main allergen, causing chronic rhinitis<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h3 class=\"\" data-start=\"3325\" data-end=\"3375\"><strong>What is important to know about interpreting results<\/strong><\/h3>\n<p class=\"\" data-start=\"3377\" data-end=\"3541\">Molecular diagnostics are not a substitute for clinical evaluation. Results should <strong data-start=\"3451\" data-end=\"3488\">be examined by an allergist<\/strong> taking into account symptoms, history, and concomitant diseases.<\/p>\n<p class=\"\" data-start=\"3543\" data-end=\"3724\">Positive test result <strong data-start=\"3570\" data-end=\"3621\">does not always mean there will be a reaction upon contact<\/strong> with an allergen. Some proteins are weak or inactive in everyday life but positive in the laboratory.<\/p>\n<h3 class=\"\" data-start=\"3726\" data-end=\"3769\"><strong>How is it different from classical methods?<\/strong><\/h3>\n<p class=\"\" data-start=\"3771\" data-end=\"3974\">Classic tests (skin tests, <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/immunoallergy-diagnostics\/general-game\/\">total IgE<\/a>) can give false positive results, especially if there is a cross-reaction \u2014 for example, a person has symptoms only to pollen, but the test will show an allergy to apple as well.<\/p>\n<p class=\"\" data-start=\"3976\" data-end=\"4155\">Molecular diagnostics allows us to separate <strong data-start=\"4019\" data-end=\"4045\">true sensitization<\/strong> \u0456 <strong data-start=\"4048\" data-end=\"4070\">cross-reaction<\/strong>, which is critically important to avoid unreasonable dietary or therapeutic restrictions.<\/p>\n<p data-start=\"3976\" data-end=\"4155\">Molecular allergy diagnostics is not just about accuracy, but a new level of understanding your own body. It allows you to focus not on limitations, but on effective allergy management.<\/p>","protected":false},"excerpt":{"rendered":"<p>Allergy is a complex and multifactorial disease that can manifest itself in the form of skin rashes, swelling, runny nose, cough, shortness of breath, or even anaphylaxis.<\/p>","protected":false},"author":627,"featured_media":8797,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8796","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0430\u043b\u0435\u0440\u0433\u0456\u0439 \u2014 \u0442\u043e\u0447\u043d\u0435 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Dzyuba","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medilab.km.ua\/wp-content\/uploads\/2026\/04\/Ulyana-Anatolivna-Dzyuba-MediLab-Plyus-150x150.jpg","url":"https:\/\/medilab.km.ua\/wp-content\/uploads\/2026\/04\/Ulyana-Anatolivna-Dzyuba-MediLab-Plyus-150x150.jpg","contentUrl":"https:\/\/medilab.km.ua\/wp-content\/uploads\/2026\/04\/Ulyana-Anatolivna-Dzyuba-MediLab-Plyus-150x150.jpg","caption":"\u0423\u043b\u044f\u043d\u0430 \u0410\u043d\u0430\u0442\u043e\u043b\u0456\u0457\u0432\u043d\u0430 \u0414\u0437\u044e\u0431\u0430"},"description":"Director of Medi Lab Plus LLC. Specialist in clinical laboratory diagnostics, clinical biochemistry and immunology. Has over 45 years of practical experience in medicine and laboratory diagnostics. Since 2007, he has been the founder and head of Medi Lab Plus LLC. She began her professional career as a nurse, later worked as an assistant epidemiologist and laboratory assistant. In 1987\u20132007, she headed a centralized serological laboratory. Education and specializations \u2022 1979 \u2014 Khmelnytskyi Basic Medical School, paramedic \u2022 1986 \u2014 Odessa State University named after I.I. Mechnikov, biologist \u2022 2001 \u2014 clinical laboratory diagnostics, NMAPE named after P.L. Shupyk \u2022 2008 \u2014 PCR diagnostics of infectious diseases, Institute of Epidemiology named after L.V. Gromashevsky \u2022 2010, 2015, 2021 \u2014 organization and management of healthcare \u2022 2017 \u2014 clinical laboratory diagnostics, Ukrainian Military Medical Academy \u2022 2017 \u2014 clinical biochemistry, Ukrainian Military Medical Academy \u2022 2018 \u2014 clinical immunology, Ukrainian Military Medical Academy \u2022 2025 \u2014 topical issues of modern medicine and pharmacy, Kharkiv Polytechnic Institute Work experience \u2022 1979\u20131982 \u2014 hospital nurse \u2022 1982\u20131986 \u2014 assistant epidemiologist \u2022 1986\u20131987 \u2014 laboratory assistant \u2022 1987\u20132007 \u2014 head of a centralized serological laboratory \u2022 Since 2007 \u2014 director of Medi Lab Plus LLC Key competencies Organization and management of medical laboratories, implementation of modern methods of laboratory diagnostics (PCR, immunological and biochemical studies), quality control of laboratory processes in accordance with state and international standards."}]}},"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=8796"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8796\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/8797"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=8796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=8796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=8796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}