{"id":8919,"date":"2024-12-21T21:54:03","date_gmt":"2024-12-21T19:54:03","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=8919"},"modified":"2026-07-23T10:27:32","modified_gmt":"2026-07-23T07:27:32","slug":"new-oncomarkers-modern-biomarkers-for-early-cancer-diagnosis","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/new-oncomarkers-modern-biomarkers-for-early-cancer-diagnosis\/","title":{"rendered":"New tumor markers: modern biomarkers for early cancer diagnosis"},"content":{"rendered":"<h3 class=\"\" data-start=\"196\" data-end=\"242\"><strong>What are tumor markers and why are they needed?<\/strong><\/h3>\n<p class=\"\" data-start=\"244\" data-end=\"526\"><a href=\"https:\/\/medilab.km.ua\/en\/what-are-oncomarkers-and-when-should-they-be-tested\/\">Tumor markers<\/a> \u2014 are specific substances (proteins, enzymes, genes, DNA fragments) that may appear in the blood, urine, or other biological fluids in response to tumor growth. Some of them are produced by the tumor cells themselves, others are produced as the body&#039;s response to the presence of a tumor.<\/p>\n<p class=\"\" data-start=\"528\" data-end=\"802\">Traditionally, the most well-known markers are PSA (prostate cancer), <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/diagnosis-of-tumor-markers\/ovarian-cancer-marker-sa-125\/\">CA-125<\/a> (ovarian cancer), CEA (colorectal cancer). However, in recent years, science has been <strong data-start=\"684\" data-end=\"715\">new generations of tumor markers<\/strong>, which are more sensitive, specific and allow for the diagnosis of cancer in the early stages.<\/p>\n<h3 class=\"\" data-start=\"804\" data-end=\"845\"><strong>What is the difference between new tumor markers?<\/strong><\/h3>\n<p class=\"\" data-start=\"847\" data-end=\"1074\">Unlike the classic ones, <strong data-start=\"873\" data-end=\"925\">new tumor markers are often molecular in nature<\/strong> are gene fragments, microRNAs, mutations, or protein complexes that more accurately indicate the type of tumor, stage of the disease, and even the prognosis for treatment.<\/p>\n<p class=\"\" data-start=\"1076\" data-end=\"1094\">They allow:<\/p>\n<ul data-start=\"1095\" data-end=\"1267\">\n<li class=\"\" data-start=\"1095\" data-end=\"1130\">\n<p class=\"\" data-start=\"1097\" data-end=\"1130\">detect cancer before symptoms appear<\/p>\n<\/li>\n<li class=\"\" data-start=\"1131\" data-end=\"1180\">\n<p class=\"\" data-start=\"1133\" data-end=\"1180\">distinguish between malignant and benign tumors<\/p>\n<\/li>\n<li class=\"\" data-start=\"1181\" data-end=\"1209\">\n<p class=\"\" data-start=\"1183\" data-end=\"1209\">assess the risk of relapse<\/p>\n<\/li>\n<li class=\"\" data-start=\"1210\" data-end=\"1267\">\n<p class=\"\" data-start=\"1212\" data-end=\"1267\">individualize therapy (personalized oncology)<\/p>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-8920\" src=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/onko2.jpg\" alt=\"Table with new biomarkers and their characteristics\" width=\"770\" height=\"330\" srcset=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/onko2.jpg 770w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/onko2-150x64.jpg 150w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/onko2-600x257.jpg 600w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/onko2-300x129.jpg 300w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/onko2-768x329.jpg 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><\/p>\n<h3 class=\"\" data-start=\"1269\" data-end=\"1300\"><strong>Examples of new tumor markers<\/strong><\/h3>\n<div class=\"overflow-x-auto contain-inline-size\">\n<div class=\"table-scroll\"><table data-start=\"1302\" data-end=\"2335\">\n<thead data-start=\"1302\" data-end=\"1405\">\n<tr data-start=\"1302\" data-end=\"1405\">\n<th data-start=\"1302\" data-end=\"1329\">Marker name<\/th>\n<th data-start=\"1329\" data-end=\"1368\">What does it reveal?<\/th>\n<th data-start=\"1368\" data-end=\"1405\">Features<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"1510\" data-end=\"2335\">\n<tr data-start=\"1510\" data-end=\"1648\">\n<td><strong data-start=\"1512\" data-end=\"1545\">Circulating Tumor DNA (ctDNA)<\/strong><\/td>\n<td>Tumor DNA fragments in the blood<\/td>\n<td>Detects mutations, suitable for early detection and monitoring<\/td>\n<\/tr>\n<tr data-start=\"1649\" data-end=\"1760\">\n<td><strong data-start=\"1651\" data-end=\"1671\">miRNA (microRNA)<\/strong><\/td>\n<td>Specific microRNAs of different cancer types<\/td>\n<td>Good sensitivity and stability in plasma<\/td>\n<\/tr>\n<tr data-start=\"1761\" data-end=\"1877\">\n<td><strong data-start=\"1763\" data-end=\"1779\">B7-H3, B7-H4<\/strong><\/td>\n<td>Breast, lung, kidney cancer<\/td>\n<td>Immunomodulatory molecules, new targets for therapy<\/td>\n<\/tr>\n<tr data-start=\"1878\" data-end=\"1994\">\n<td><strong data-start=\"1880\" data-end=\"1908\">Thymidine Kinase 1 (TK1)<\/strong><\/td>\n<td>Tumor cell activity<\/td>\n<td>Well suited for monitoring chemotherapy<\/td>\n<\/tr>\n<tr data-start=\"1995\" data-end=\"2112\">\n<td><strong data-start=\"1997\" data-end=\"2022\">HE4 (together with CA-125)<\/strong><\/td>\n<td>Ovarian cancer<\/td>\n<td>Higher accuracy when combined with other markers<\/td>\n<\/tr>\n<tr data-start=\"2113\" data-end=\"2215\">\n<td><strong data-start=\"2115\" data-end=\"2140\">M2-PK (pyruvate kinase)<\/strong><\/td>\n<td>Colorectal cancer<\/td>\n<td>Effective in fecal screening<\/td>\n<\/tr>\n<tr data-start=\"2216\" data-end=\"2335\">\n<td><strong data-start=\"2218\" data-end=\"2247\">Autoantibodies (ANA, p53)<\/strong><\/td>\n<td>Early immune responses<\/td>\n<td>Promising for \u201cpre-clinical\u201d tests\u201d<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/div>\n<h3 class=\"\" data-start=\"2337\" data-end=\"2375\"><strong>How are new tumor markers used?<\/strong><\/h3>\n<ol data-start=\"2377\" data-end=\"2824\">\n<li class=\"\" data-start=\"2377\" data-end=\"2477\">\n<p class=\"\" data-start=\"2380\" data-end=\"2477\"><strong data-start=\"2380\" data-end=\"2399\">Early detection<\/strong>: For example, ctDNA can detect a tumor before an MRI or ultrasound can see it.<\/p>\n<\/li>\n<li class=\"\" data-start=\"2478\" data-end=\"2588\">\n<p class=\"\" data-start=\"2481\" data-end=\"2588\"><strong data-start=\"2481\" data-end=\"2527\">Monitoring after surgery or chemotherapy<\/strong>: The appearance of ctDNA may indicate micrometastases or recurrence.<\/p>\n<\/li>\n<li class=\"\" data-start=\"2589\" data-end=\"2711\">\n<p class=\"\" data-start=\"2592\" data-end=\"2711\"><strong data-start=\"2592\" data-end=\"2632\">Predicting response to treatment<\/strong>: TK1 levels or changes in microRNAs help assess whether the chosen therapy is working.<\/p>\n<\/li>\n<li class=\"\" data-start=\"2712\" data-end=\"2824\">\n<p class=\"\" data-start=\"2715\" data-end=\"2824\"><strong data-start=\"2715\" data-end=\"2739\">Screening of risk groups<\/strong>: In patients with a hereditary predisposition, certain biomarkers can be monitored periodically.<\/p>\n<\/li>\n<\/ol>\n<h3 class=\"\" data-start=\"2826\" data-end=\"2853\"><strong>Limitations and prospects<\/strong><\/h3>\n<p class=\"\" data-start=\"2855\" data-end=\"3210\">Despite the encouraging results, <strong data-start=\"2893\" data-end=\"2966\">most new tumor markers do not yet have the status of &quot;gold standard&quot;\u00ab<\/strong>. They are used mainly in research centers or in experimental therapy settings. However, they are already entering clinical practice in leading medical institutions in the EU and the USA (in particular, with the support of programs <strong data-start=\"3180\" data-end=\"3208\">FDA Breakthrough Devices<\/strong>).<\/p>\n<p class=\"\" data-start=\"3212\" data-end=\"3402\">Also under development <strong data-start=\"3232\" data-end=\"3254\">multigene panels<\/strong> \u2014 tests that detect dozens of different biomarkers in a single sample, allowing for coverage of several types of cancer simultaneously (for example, Galleri by GRAIL).<\/p>\n<h3 class=\"\" data-start=\"3404\" data-end=\"3428\"><strong>References to sources<\/strong><\/h3>\n<ol data-start=\"3430\" data-end=\"3881\">\n<li class=\"\" data-start=\"3430\" data-end=\"3522\">\n<p class=\"\" data-start=\"3433\" data-end=\"3522\">WHO \u2013 <a class=\"\" href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer\" target=\"_new\" rel=\"noopener\" data-start=\"3439\" data-end=\"3520\">Early cancer diagnosis<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3523\" data-end=\"3631\">\n<p class=\"\" data-start=\"3526\" data-end=\"3631\">FDA \u2013 <a class=\"cursor-pointer\" target=\"_new\" rel=\"noopener\" data-start=\"3532\" data-end=\"3629\">Biomarker Qualification Program<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3632\" data-end=\"3765\">\n<p class=\"\" data-start=\"3635\" data-end=\"3765\">Mayo Clinic \u2013 <a class=\"\" href=\"https:\/\/www.mayoclinic.org\/tests-procedures\/tumor-markers\/about\/pac-20385098\" target=\"_new\" rel=\"noopener\" data-start=\"3649\" data-end=\"3763\">Emerging tumor markers in oncology<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3766\" data-end=\"3881\">\n<p class=\"\" data-start=\"3769\" data-end=\"3881\">Nature Reviews Cancer \u2013 The evolving role of liquid biopsy<\/p>\n<\/li>\n<\/ol>\n<p>Oncology ceases to be a sentence precisely thanks to such technologies. It is important to remember: the earlier, the better the chances of recovery. And science today gives us powerful tools for this.<\/p>","protected":false},"excerpt":{"rendered":"<p>What are tumor markers and why are they needed? Tumor markers are specific substances (proteins, enzymes, genes, DNA fragments) that can appear<\/p>","protected":false},"author":627,"featured_media":8921,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,233],"tags":[],"class_list":["post-8919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zahvoryuvannya-ta-symptomy","category-rozshyfrovka-analiziv-ta-pidgotovka"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=8919"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8919\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/8921"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=8919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=8919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=8919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}