{"id":8924,"date":"2025-04-05T12:09:01","date_gmt":"2025-04-05T09:09:01","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=8924"},"modified":"2026-04-20T18:54:33","modified_gmt":"2026-04-20T15:54:33","slug":"allergen-panel-modern-laboratory-diagnostics-for-accurate-allergy-detection","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/allergen-panel-modern-laboratory-diagnostics-for-accurate-allergy-detection\/","title":{"rendered":"Allergen panel: modern laboratory diagnostics for accurate allergy detection"},"content":{"rendered":"<h3 class=\"\" data-start=\"181\" data-end=\"245\"><strong>Relevance: why allergy diagnosis needs new solutions<\/strong><\/h3>\n<p class=\"\" data-start=\"247\" data-end=\"601\">Allergy is one of the most common chronic diseases in the world. According to WHO estimates, allergic reactions affect more than 30% of the world&#039;s population. Often, symptoms - from nasal congestion to anaphylaxis - appear suddenly, and the source remains unknown. In such cases <strong data-start=\"510\" data-end=\"530\">allergen panel<\/strong> allows not only to establish the cause, but also to predict the degree of risk.<\/p>\n<p class=\"\" data-start=\"603\" data-end=\"769\">Unlike spot tests, a panel covers dozens or hundreds of potential allergens in a single blood sample. It is a method that combines accuracy, safety, and speed.<\/p>\n<h3 class=\"\" data-start=\"771\" data-end=\"805\"><strong>What is included in the allergen panel?<\/strong><\/h3>\n<p class=\"\" data-start=\"807\" data-end=\"934\">An allergen panel is a set of reagents for determining <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/immunoallergy-diagnostics\/specific-ig-e\/ige-specific-90-food-products-dyv-addendum1\/\">specific IgE antibodies<\/a> to specific substances. Panels are divided into types:<\/p>\n<ul data-start=\"936\" data-end=\"1268\">\n<li class=\"\" data-start=\"936\" data-end=\"1005\">\n<p class=\"\" data-start=\"938\" data-end=\"1005\"><strong data-start=\"938\" data-end=\"953\">Inhalation<\/strong>: plant pollen, mites, animal hair, fungal spores<\/p>\n<\/li>\n<li class=\"\" data-start=\"1006\" data-end=\"1067\">\n<p class=\"\" data-start=\"1008\" data-end=\"1067\"><strong data-start=\"1008\" data-end=\"1019\">Food<\/strong>: dairy products, eggs, nuts, fish, fruits<\/p>\n<\/li>\n<li class=\"\" data-start=\"1068\" data-end=\"1131\">\n<p class=\"\" data-start=\"1070\" data-end=\"1131\"><strong data-start=\"1070\" data-end=\"1081\">Mixed<\/strong>: combination of respiratory and food allergens<\/p>\n<\/li>\n<li class=\"\" data-start=\"1132\" data-end=\"1175\">\n<p class=\"\" data-start=\"1134\" data-end=\"1175\"><strong data-start=\"1134\" data-end=\"1144\">Children&#039;s<\/strong>: optimized for early age<\/p>\n<\/li>\n<li class=\"\" data-start=\"1176\" data-end=\"1268\">\n<p class=\"\" data-start=\"1178\" data-end=\"1268\"><strong data-start=\"1178\" data-end=\"1199\">Molecular (CRD)<\/strong>: detects a reaction to specific proteins (e.g. Ara h 2 in peanuts)<\/p>\n<\/li>\n<\/ul>\n<p class=\"\" data-start=\"1270\" data-end=\"1390\">Modern platforms like <strong data-start=\"1295\" data-end=\"1304\">ALEX\u00b2<\/strong>, <strong data-start=\"1306\" data-end=\"1324\">ImmunoCAP ISAC<\/strong>, allow testing for over 280 allergens simultaneously.<\/p>\n<h3 class=\"\" data-start=\"1392\" data-end=\"1415\"><strong>How is the test performed?<\/strong><\/h3>\n<ol data-start=\"1417\" data-end=\"1663\">\n<li class=\"\" data-start=\"1417\" data-end=\"1478\">\n<p class=\"\" data-start=\"1420\" data-end=\"1478\"><strong data-start=\"1420\" data-end=\"1435\">Preparation:<\/strong> Blood is donated in the morning, preferably on an empty stomach.<\/p>\n<\/li>\n<li class=\"\" data-start=\"1479\" data-end=\"1522\">\n<p class=\"\" data-start=\"1482\" data-end=\"1522\"><strong data-start=\"1482\" data-end=\"1498\">Blood sampling:<\/strong> from a vein (1 tube).<\/p>\n<\/li>\n<li class=\"\" data-start=\"1523\" data-end=\"1592\">\n<p class=\"\" data-start=\"1526\" data-end=\"1592\"><strong data-start=\"1526\" data-end=\"1554\">Laboratory study:<\/strong> Specific IgE levels are determined.<\/p>\n<\/li>\n<li class=\"\" data-start=\"1593\" data-end=\"1663\">\n<p class=\"\" data-start=\"1596\" data-end=\"1663\"><strong data-start=\"1596\" data-end=\"1610\">Result:<\/strong> a digital profile of allergen sensitivity is formed.<\/p>\n<\/li>\n<\/ol>\n<p class=\"\" data-start=\"1665\" data-end=\"1755\">The method is based on <strong data-start=\"1684\" data-end=\"1712\">enzyme immunoassay<\/strong> or <strong data-start=\"1717\" data-end=\"1754\">multiplex immunofluorescence<\/strong>.<\/p>\n<p data-start=\"1665\" data-end=\"1755\"><img decoding=\"async\" class=\"alignnone size-full wp-image-8926\" src=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2.jpg\" alt=\"Allergy panel results screen\" width=\"1200\" height=\"800\" srcset=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2.jpg 1200w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2-150x100.jpg 150w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2-600x400.jpg 600w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2-300x200.jpg 300w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2-1024x683.jpg 1024w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/skin-allergy-person-s-arm-2-768x512.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<h3 class=\"\" data-start=\"1757\" data-end=\"1796\"><strong>Example of an allergen panel result<\/strong><\/h3>\n<div class=\"overflow-x-auto contain-inline-size\">\n<table data-start=\"1798\" data-end=\"2714\">\n<thead data-start=\"1798\" data-end=\"1910\">\n<tr data-start=\"1798\" data-end=\"1910\">\n<th data-start=\"1798\" data-end=\"1826\">Allergen<\/th>\n<th data-start=\"1826\" data-end=\"1847\">IgE level (IU\/ml)<\/th>\n<th data-start=\"1847\" data-end=\"1869\">Sensitization class<\/th>\n<th data-start=\"1869\" data-end=\"1910\">Comment<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"2026\" data-end=\"2714\">\n<tr data-start=\"2026\" data-end=\"2140\">\n<td>Weed (ragweed)<\/td>\n<td>0.4<\/td>\n<td>Class 1<\/td>\n<td>Very low sensitivity<\/td>\n<\/tr>\n<tr data-start=\"2141\" data-end=\"2255\">\n<td>House dust mites<\/td>\n<td>2.6<\/td>\n<td>Class 2<\/td>\n<td>Mild reaction possible<\/td>\n<\/tr>\n<tr data-start=\"2256\" data-end=\"2370\">\n<td>Latex<\/td>\n<td>8.5<\/td>\n<td>Class 3<\/td>\n<td>Moderate sensitization<\/td>\n<\/tr>\n<tr data-start=\"2371\" data-end=\"2484\">\n<td>Egg white (ovomucoid)<\/td>\n<td>15.2<\/td>\n<td>Class 4<\/td>\n<td>High probability of clinical response<\/td>\n<\/tr>\n<tr data-start=\"2485\" data-end=\"2599\">\n<td>Cow&#039;s milk<\/td>\n<td>38.4<\/td>\n<td>Class 5<\/td>\n<td>Severe sensitization<\/td>\n<\/tr>\n<tr data-start=\"2600\" data-end=\"2714\">\n<td>Peanuts (Ara h 2)<\/td>\n<td>62.1<\/td>\n<td>Class 6<\/td>\n<td>Potentially dangerous reaction<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"\" data-start=\"2716\" data-end=\"2733\">IgE classification:<\/p>\n<ul data-start=\"2735\" data-end=\"2916\">\n<li class=\"\" data-start=\"2735\" data-end=\"2782\">\n<p class=\"\" data-start=\"2737\" data-end=\"2782\"><strong data-start=\"2737\" data-end=\"2747\">Class 0<\/strong>: &lt; 0.35 IU\/ml \u2014 no sensitivity<\/p>\n<\/li>\n<li class=\"\" data-start=\"2783\" data-end=\"2828\">\n<p class=\"\" data-start=\"2785\" data-end=\"2828\"><strong data-start=\"2785\" data-end=\"2797\">Class 1\u20132<\/strong>: low\/slight sensitization<\/p>\n<\/li>\n<li class=\"\" data-start=\"2829\" data-end=\"2871\">\n<p class=\"\" data-start=\"2831\" data-end=\"2871\"><strong data-start=\"2831\" data-end=\"2843\">Grade 3\u20134<\/strong>: clinically significant allergy<\/p>\n<\/li>\n<li class=\"\" data-start=\"2872\" data-end=\"2916\">\n<p class=\"\" data-start=\"2874\" data-end=\"2916\"><strong data-start=\"2874\" data-end=\"2886\">Grade 5\u20136<\/strong>: high risk of severe reactions<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"2918\" data-end=\"2955\"><strong>Who is recommended to take the test?<\/strong><\/h3>\n<ul data-start=\"2957\" data-end=\"3280\">\n<li class=\"\" data-start=\"2957\" data-end=\"3014\">\n<p class=\"\" data-start=\"2959\" data-end=\"3014\">People with <strong data-start=\"2967\" data-end=\"2988\">chronic runny nose<\/strong>, conjunctivitis, cough<\/p>\n<\/li>\n<li class=\"\" data-start=\"3015\" data-end=\"3061\">\n<p class=\"\" data-start=\"3017\" data-end=\"3061\">Patients with <strong data-start=\"3030\" data-end=\"3045\">dermatitis<\/strong>, urticaria<\/p>\n<\/li>\n<li class=\"\" data-start=\"3062\" data-end=\"3110\">\n<p class=\"\" data-start=\"3064\" data-end=\"3110\">For persons with <strong data-start=\"3074\" data-end=\"3108\">unknown food reactions<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"3111\" data-end=\"3161\">\n<p class=\"\" data-start=\"3113\" data-end=\"3161\">For children before introducing complementary foods or vaccinations<\/p>\n<\/li>\n<li class=\"\" data-start=\"3162\" data-end=\"3235\">\n<p class=\"\" data-start=\"3164\" data-end=\"3235\">For control <strong data-start=\"3177\" data-end=\"3233\">effectiveness of ASIT (allergen-specific immunotherapy)<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"3236\" data-end=\"3280\">\n<p class=\"\" data-start=\"3238\" data-end=\"3280\">At <strong data-start=\"3242\" data-end=\"3278\">genetic predisposition to allergies<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"3282\" data-end=\"3311\"><strong>Benefits of an allergen panel<\/strong><\/h3>\n<ul data-start=\"3313\" data-end=\"3595\">\n<li class=\"\" data-start=\"3313\" data-end=\"3366\">\n<p class=\"\" data-start=\"3315\" data-end=\"3366\">Simultaneous testing of a large number of allergens<\/p>\n<\/li>\n<li class=\"\" data-start=\"3367\" data-end=\"3415\">\n<p class=\"\" data-start=\"3369\" data-end=\"3415\">Detection capability <strong data-start=\"3390\" data-end=\"3413\">cross-allergy<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"3416\" data-end=\"3492\">\n<p class=\"\" data-start=\"3418\" data-end=\"3492\">Using <strong data-start=\"3431\" data-end=\"3459\">molecular diagnostics<\/strong> \u2014 accurate and prognostically significant<\/p>\n<\/li>\n<li class=\"\" data-start=\"3493\" data-end=\"3533\">\n<p class=\"\" data-start=\"3495\" data-end=\"3533\">A safe alternative to skin tests<\/p>\n<\/li>\n<li class=\"\" data-start=\"3534\" data-end=\"3595\">\n<p class=\"\" data-start=\"3536\" data-end=\"3595\">Suitable for people with <strong data-start=\"3554\" data-end=\"3595\">atopic dermatitis, pregnant women, children<\/strong><\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"3597\" data-end=\"3621\"><strong>References to sources<\/strong><\/h3>\n<ol data-start=\"3623\" data-end=\"4085\">\n<li class=\"\" data-start=\"3623\" data-end=\"3752\">\n<p class=\"\" data-start=\"3626\" data-end=\"3752\">World Health Organization \u2013 <a class=\"\" href=\"https:\/\/www.who.int\/publications\/i\/item\/allergy-diagnosis\" target=\"_new\" rel=\"noopener\" data-start=\"3654\" data-end=\"3750\">Allergy diagnosis and immunotherapy<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3753\" data-end=\"3871\">\n<p class=\"\" data-start=\"3756\" data-end=\"3871\">Mayo Clinic \u2013 <a class=\"\" href=\"https:\/\/www.mayoclinic.org\/tests-procedures\/allergy-tests\/about\/pac-20392895\" target=\"_new\" rel=\"noopener\" data-start=\"3770\" data-end=\"3869\">Allergy blood tests<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3872\" data-end=\"4004\">\n<p class=\"\" data-start=\"3875\" data-end=\"4004\">European Academy of Allergy and Clinical Immunology \u2013 <a class=\"cursor-pointer\" target=\"_new\" rel=\"noopener\" data-start=\"3929\" data-end=\"4002\">Molecular allergology guide<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"4005\" data-end=\"4085\">\n<p class=\"\" data-start=\"4008\" data-end=\"4085\">FDA \u2013 <a class=\"cursor-pointer\" target=\"_new\" rel=\"noopener\" data-start=\"4014\" data-end=\"4085\">Diagnostic testing for allergens<\/a><\/p>\n<\/li>\n<\/ol>\n<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-288\" data-scroll-anchor=\"true\">\n<div class=\"text-base my-auto mx-auto py-5 px-6\">\n<div class=\"mx-auto flex flex-1 text-base gap-4 md:gap-5 lg:gap-6 md:max-w-3xl lg:max-w-[40rem] xl:max-w-[48rem] group\/turn-messages focus-visible:outline-hidden\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn @xs\/thread:px-0 @sm\/thread:px-1.5 @md\/thread:px-4\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"ee5bb2c2-ab15-47bd-aea1-9d001347c8b2\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light\">\n<p class=\"\" data-start=\"4818\" data-end=\"5018\">An allergen panel is a tool that helps you go beyond guesswork and pinpoint the culprits of your allergies. It allows you to not only confirm a diagnosis, but also choose a treatment path that actually works.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>","protected":false},"excerpt":{"rendered":"<p>Relevance: why allergy diagnostics need new solutions Allergy is one of the most common chronic pathologies in the world. According to WHO estimates, allergic<\/p>","protected":false},"author":627,"featured_media":8925,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8924","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=8924"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8924\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/8925"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=8924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=8924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=8924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}