{"id":8953,"date":"2024-12-13T15:51:46","date_gmt":"2024-12-13T13:51:46","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=8953"},"modified":"2026-04-20T18:54:45","modified_gmt":"2026-04-20T15:54:45","slug":"microbiome-and-immunity-are-key-biological-interactions-for-human-health","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/microbiome-and-immunity-are-key-biological-interactions-for-human-health\/","title":{"rendered":"Microbiome and immunity: a key biological interaction for human health"},"content":{"rendered":"<h3 class=\"\" data-start=\"207\" data-end=\"268\"><strong>Biological Alliance: How the Microbiome Maintains Immune Balance<\/strong><\/h3>\n<p class=\"\" data-start=\"270\" data-end=\"561\">The microbiome is a complex community of microorganisms that inhabit the human body, especially the gut. Its interaction with the immune system is two-way: the immune system controls the microbiota, and the microbiota trains the immune system. This symbiotic interaction begins at birth and continues throughout life.<\/p>\n<p class=\"\" data-start=\"563\" data-end=\"819\">Modern science confirms that a full immune response is impossible without a healthy microflora. The formation of tolerance to non-aggressive agents, anti-inflammatory control, effective protection against pathogens - all this depends on the composition and activity of the microbiome.<\/p>\n<h3 class=\"\" data-start=\"821\" data-end=\"874\"><strong>Formation of the immune system under the influence of microbiota<\/strong><\/h3>\n<p class=\"\" data-start=\"876\" data-end=\"1148\">In newborns, the microbiota begins to form immediately after birth. The method of birth (natural birth or cesarean section), breastfeeding, contact with the environment - all this determines the early composition of the microflora. It is during this period that the initial \u201ctraining\u201d of immunity takes place:<\/p>\n<ul data-start=\"1150\" data-end=\"1437\">\n<li class=\"\" data-start=\"1150\" data-end=\"1201\">\n<p class=\"\" data-start=\"1152\" data-end=\"1201\">maturation of intestinal lymphoid tissue (GALT)<\/p>\n<\/li>\n<li class=\"\" data-start=\"1202\" data-end=\"1267\">\n<p class=\"\" data-start=\"1204\" data-end=\"1267\">stimulation of the production of IgA - a protective immunoglobulin of the mucous membranes<\/p>\n<\/li>\n<li class=\"\" data-start=\"1268\" data-end=\"1345\">\n<p class=\"\" data-start=\"1270\" data-end=\"1345\">formation of T-regulatory cells responsible for immune tolerance<\/p>\n<\/li>\n<li class=\"\" data-start=\"1346\" data-end=\"1437\">\n<p class=\"\" data-start=\"1348\" data-end=\"1437\">synthesis of signaling molecules (interleukins, interferons) that regulate the inflammatory response<\/p>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-8955\" src=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/888-1.jpg\" alt=\"Scheme: microbiome\u2013immunity\u2013health\" width=\"700\" height=\"394\" srcset=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/888-1.jpg 700w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/888-1-150x84.jpg 150w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/888-1-600x338.jpg 600w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/04\/888-1-300x169.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<h3 class=\"\" data-start=\"1439\" data-end=\"1474\"><strong>Interaction in the adult body<\/strong><\/h3>\n<p class=\"\" data-start=\"1476\" data-end=\"1757\">In adulthood, the microbiome functions as a stabilizer of immune homeostasis. Its bacterial metabolites, including butyrate, propionate, and acetate, reduce the expression of pro-inflammatory genes, enhance the barrier function of the intestinal epithelium, and reduce the activity of harmful microorganisms.<\/p>\n<p class=\"\" data-start=\"1759\" data-end=\"2002\">Research indicates that <strong data-start=\"1784\" data-end=\"1830\">The microbiome is essential for immune memory<\/strong>, as it modulates T-cell activation and optimizes the response to vaccination. For example, the level of effectiveness of the flu vaccine is directly correlated with the state of the intestinal microflora.<\/p>\n<h3 class=\"\" data-start=\"2004\" data-end=\"2059\"><strong>Examples of microbiome-related immune disorders<\/strong><\/h3>\n<p class=\"\" data-start=\"2061\" data-end=\"2127\">Disruption of the microbiota balance (dysbiosis) is associated with a number of diseases:<\/p>\n<ul data-start=\"2129\" data-end=\"2489\">\n<li class=\"\" data-start=\"2129\" data-end=\"2228\">\n<p class=\"\" data-start=\"2131\" data-end=\"2228\">Allergic reactions \u2014 reduced bacterial diversity in children increases the risk of asthma and atopy<\/p>\n<\/li>\n<li class=\"\" data-start=\"2229\" data-end=\"2317\">\n<p class=\"\" data-start=\"2231\" data-end=\"2317\">Autoimmune diseases \u2014 changes in microflora in patients with rheumatoid arthritis, type 1 diabetes<\/p>\n<\/li>\n<li class=\"\" data-start=\"2318\" data-end=\"2422\">\n<p class=\"\" data-start=\"2320\" data-end=\"2422\">Infectious diseases - deficiency of bacteria that activate the antiviral response (e.g., in COVID-19)<\/p>\n<\/li>\n<li class=\"\" data-start=\"2423\" data-end=\"2489\">\n<p class=\"\" data-start=\"2425\" data-end=\"2489\">Immunodeficiencies \u2014 prolonged antibiotic therapy reduces IgA production<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"2491\" data-end=\"2551\"><strong><a href=\"https:\/\/medilab.km.ua\/en\/influence-of-the-microbiome-on-health-and-novyj-poglyad-na-fundamentalni-protsesy-v-organismi\/\">The main mechanisms of the microbiome&#039;s influence on immunity<\/a><\/strong><\/h3>\n<div class=\"overflow-x-auto contain-inline-size\">\n<table data-start=\"2553\" data-end=\"3237\">\n<thead data-start=\"2553\" data-end=\"2666\">\n<tr data-start=\"2553\" data-end=\"2666\">\n<th data-start=\"2553\" data-end=\"2581\">Mechanism<\/th>\n<th data-start=\"2581\" data-end=\"2626\">Impact on the immune system<\/th>\n<th data-start=\"2626\" data-end=\"2666\">With dysbiosis<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"2782\" data-end=\"3237\">\n<tr data-start=\"2782\" data-end=\"2895\">\n<td>SCFA products<\/td>\n<td>Reduces inflammation, strengthens the mucosal barrier<\/td>\n<td>Chronic intestinal inflammation<\/td>\n<\/tr>\n<tr data-start=\"2896\" data-end=\"3011\">\n<td>IgA secretion<\/td>\n<td>Mucous membrane protection<\/td>\n<td>Frequent respiratory and intestinal infections<\/td>\n<\/tr>\n<tr data-start=\"3012\" data-end=\"3125\">\n<td>Activation of T-regulators<\/td>\n<td>Forms immune tolerance<\/td>\n<td>Risk of autoimmune processes<\/td>\n<\/tr>\n<tr data-start=\"3126\" data-end=\"3237\">\n<td>Stimulation of antimicrobial peptides<\/td>\n<td>Destruction of pathogens<\/td>\n<td>Growth of opportunistic flora<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h3 class=\"\" data-start=\"3239\" data-end=\"3284\"><strong>Supporting immune function through the microbiome<\/strong><\/h3>\n<p class=\"\" data-start=\"3286\" data-end=\"3379\">Maintaining a healthy microbiome means maintaining a strong immune system. To do this, you need to:<\/p>\n<ul data-start=\"3381\" data-end=\"3771\">\n<li class=\"\" data-start=\"3381\" data-end=\"3461\">\n<p class=\"\" data-start=\"3383\" data-end=\"3461\">to use regularly <a href=\"https:\/\/medilab.km.ua\/en\/influence-of-the-microbiome-on-health-and-novyj-poglyad-na-fundamentalni-protsesy-v-organismi\/\"><strong data-start=\"3401\" data-end=\"3415\">prebiotics<\/strong> <\/a>(fiber, inulin, resistant starch)<\/p>\n<\/li>\n<li class=\"\" data-start=\"3462\" data-end=\"3544\">\n<p class=\"\" data-start=\"3464\" data-end=\"3544\">comprise <strong data-start=\"3473\" data-end=\"3498\">fermented foods<\/strong> (natural yogurt, kefir, kimchi, kombucha)<\/p>\n<\/li>\n<li class=\"\" data-start=\"3545\" data-end=\"3607\">\n<p class=\"\" data-start=\"3547\" data-end=\"3607\">reduce consumption <strong data-start=\"3567\" data-end=\"3605\">refined sugar and emulsifiers<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"3608\" data-end=\"3661\">\n<p class=\"\" data-start=\"3610\" data-end=\"3661\">avoid <strong data-start=\"3618\" data-end=\"3659\">unjustified use of antibiotics<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"3662\" data-end=\"3714\">\n<p class=\"\" data-start=\"3664\" data-end=\"3714\">to provide <strong data-start=\"3676\" data-end=\"3712\">physical activity and quality sleep<\/strong><\/p>\n<\/li>\n<li class=\"\" data-start=\"3715\" data-end=\"3771\">\n<p class=\"\" data-start=\"3717\" data-end=\"3771\">reduce <strong data-start=\"3727\" data-end=\"3736\">stress<\/strong>, which disrupts the bacterial balance<\/p>\n<\/li>\n<\/ul>\n<h3 class=\"\" data-start=\"3773\" data-end=\"3784\"><strong>Sources<\/strong><\/h3>\n<ul data-start=\"3786\" data-end=\"4132\">\n<li class=\"\" data-start=\"3786\" data-end=\"3892\">\n<p class=\"\" data-start=\"3788\" data-end=\"3892\">WHO \u2013 <a class=\"\" href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/human-microbiome\" target=\"_new\" rel=\"noopener\" data-start=\"3794\" data-end=\"3890\">Human microbiome and health<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3893\" data-end=\"3990\">\n<p class=\"\" data-start=\"3895\" data-end=\"3990\">Mayo Clinic \u2013 <a class=\"\" href=\"https:\/\/www.mayoclinic.org\/gut-microbiota-immunity\" target=\"_new\" rel=\"noopener\" data-start=\"3909\" data-end=\"3988\">Gut bacteria and immunity<\/a><\/p>\n<\/li>\n<li class=\"\" data-start=\"3991\" data-end=\"4060\">\n<p class=\"\" data-start=\"3993\" data-end=\"4060\"><em data-start=\"3993\" data-end=\"4012\">Nature Immunology<\/em> \u2013 <em data-start=\"4015\" data-end=\"4058\">Gut microbiota as a regulator of immunity<\/em><\/p>\n<\/li>\n<li class=\"\" data-start=\"4061\" data-end=\"4132\">\n<p class=\"\" data-start=\"4063\" data-end=\"4132\">FDA \u2013 <a class=\"\" href=\"https:\/\/www.fda.gov\" target=\"_new\" rel=\"noopener\" data-start=\"4069\" data-end=\"4132\">Regulation of microbiome-based therapies<\/a><\/p>\n<\/li>\n<\/ul>\n<p>The microbiome is not just part of the digestive system. It is a full-fledged immune regulator that influences our health on a daily basis. Supporting it is a strategy not only for disease prevention, but also for overall immune balance.<\/p>","protected":false},"excerpt":{"rendered":"<p>Biological Alliance: How the Microbiome Maintains Immune Balance The microbiome is the complex community of microorganisms that inhabit the human body, especially the gut. Its<\/p>","protected":false},"author":627,"featured_media":8954,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=8953"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/8953\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/8954"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=8953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=8953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=8953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}