{"id":9195,"date":"2024-11-13T14:35:56","date_gmt":"2024-11-13T12:35:56","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=9195"},"modified":"2026-04-20T18:54:48","modified_gmt":"2026-04-20T15:54:48","slug":"liquid-biopsy-a-new-era-in-cancer-diagnosis","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/liquid-biopsy-a-new-era-in-cancer-diagnosis\/","title":{"rendered":"Liquid biopsy: a new era in cancer diagnosis"},"content":{"rendered":"
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\n 4.8\/5 - (916 votes) <\/div>\n <\/div>\n

What is a liquid biopsy?<\/strong><\/h2>\n

Liquid biopsy is non-invasive method of detecting cancer cells or tumor genetic material in biological fluids<\/strong>, most often in the blood. Unlike a traditional biopsy, which requires a tissue sample, a liquid biopsy allows for the analysis of tumor changes without surgical intervention<\/strong>.<\/p>\n

The main goal is detection of circulating tumor DNA (ctDNA)<\/strong>, tumor cells or exosomes that enter the bloodstream from the primary or metastatic site.<\/p>\n

This method is already actively used in the USA, Europe and is being implemented in clinical practice in Ukraine, in particular within the framework of precision oncology<\/strong>.<\/p>\n

What liquids can be used?<\/strong><\/h2>\n
    \n
  • \n

    Blood (plasma)<\/strong> \u2014 most often<\/p>\n<\/li>\n

  • \n

    Urine<\/strong> \u2014 for some urological tumors<\/p>\n<\/li>\n

  • \n

    Cerebrospinal fluid<\/strong> \u2014 for brain tumors<\/p>\n<\/li>\n

  • \n

    Saliva, bile, pleural effusion<\/strong> \u2014 for research in individual cases<\/p>\n<\/li>\n<\/ul>\n

    What can a liquid biopsy detect?<\/strong><\/h2>\n
    \n
    \n\n\n\n\n\n\n\n\n\n
    Possibility<\/strong><\/th>\nPractical application<\/strong><\/th>\n<\/tr>\n<\/thead>\n
    Detection of mutations in ctDNA<\/td>\nChoosing targeted therapy (EGFR, KRAS, BRAF, ALK, and others)<\/td>\n<\/tr>\n
    Definition of minimal residual disease<\/td>\nMonitoring after surgery or chemotherapy<\/td>\n<\/tr>\n
    Early diagnosis<\/td>\nTumor detection before clinical symptoms appear<\/td>\n<\/tr>\n
    Evaluation of treatment effectiveness<\/td>\nDecreasing ctDNA levels indicate a response to therapy<\/td>\n<\/tr>\n
    Relapse detection<\/td>\nctDNA appears in the blood even before clinical progression<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

    Oncologist Igor Savin explains:
    \u00abLiquid biopsy does not replace tissue biopsy, but it gives the doctor a unique tool to track changes in the tumor in almost real time. This is invaluable in the treatment of metastatic forms of cancer.\u00bb<\/em><\/p>\n

    \"a<\/p>\n

    Advantages of liquid biopsy<\/strong><\/h2>\n
      \n
    • \n

      Security<\/strong> \u2014 does not require surgical intervention<\/p>\n<\/li>\n

    • \n

      Patient comfort<\/strong> \u2014 routine blood draw<\/p>\n<\/li>\n

    • \n

      Possibility of multiple control<\/strong> \u2014 dynamics of tumor changes<\/p>\n<\/li>\n

    • \n

      Access to genetic information<\/strong> \u2014 even if the fabric is not available<\/p>\n<\/li>\n

    • \n

      Speed of getting results<\/strong> \u2014 7\u201310 days in most laboratories<\/p>\n<\/li>\n<\/ul>\n

      Who can be prescribed a liquid biopsy?<\/strong><\/h2>\n
        \n
      • \n

        Patients with suspected cancer<\/strong>, from which it is impossible to take a tissue sample<\/p>\n<\/li>\n

      • \n

        Patients who are already receiving targeted or immunotherapy<\/strong><\/p>\n<\/li>\n

      • \n

        If necessary residual disease assessments<\/strong> after treatment<\/p>\n<\/li>\n

      • \n

        For choosing an individual treatment protocol<\/strong> in case of relapse<\/p>\n<\/li>\n

      • \n

        Within screening programs<\/strong> (at the stage of clinical trials)<\/p>\n<\/li>\n<\/ul>\n

        Liquid biopsy and precision oncology<\/strong><\/h2>\n

        Modern oncology is moving from a \u00abone treatment fits all\u00bb approach to individual therapy<\/strong>, which is based on mutational profile of the tumor<\/strong>. Liquid biopsy allows:<\/p>\n

          \n
        • \n

          to find the exact genetic target<\/strong><\/p>\n<\/li>\n

        • \n

          change therapy if any appear new mutations<\/strong><\/p>\n<\/li>\n

        • \n

          monitor resistance<\/strong> to drugs<\/p>\n<\/li>\n

        • \n

          save time on expensive tests if treatment is ineffective<\/p>\n<\/li>\n<\/ul>\n

          Limitations and challenges<\/strong><\/h2>\n
            \n
          • \n

            Not all tumors secrete sufficient amounts of ctDNA<\/strong><\/p>\n<\/li>\n

          • \n

            Maybe not sensitive enough<\/strong> in the early stages<\/p>\n<\/li>\n

          • \n

            Needed high standardization of laboratories and technologies<\/strong><\/p>\n<\/li>\n

          • \n

            Price<\/strong> research still remains high for widespread use<\/p>\n<\/li>\n<\/ul>\n

            Liquid biopsy is technology of the future<\/strong>, which is already changing the lives of cancer patients. It allows you to see the tumor not only under a microscope, but also at the molecular level<\/strong>, respond to changes instantly and build treatment based on an individual genetic portrait.<\/p>","protected":false},"excerpt":{"rendered":"

            What is a liquid biopsy? 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