{"id":9718,"date":"2025-05-28T03:05:13","date_gmt":"2025-05-28T00:05:13","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=9718"},"modified":"2026-04-20T18:53:44","modified_gmt":"2026-04-20T15:53:44","slug":"the-influence-of-the-microbiome-on-the-digestion-of-food-that-occurs-in-the-intestine","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/the-influence-of-the-microbiome-on-the-digestion-of-food-that-occurs-in-the-intestine\/","title":{"rendered":"The impact of the microbiome on food digestion: what happens in the gut"},"content":{"rendered":"<p data-start=\"242\" data-end=\"574\">The microorganisms that live inside us may seem like outsiders, but without them, digestion would be incomplete. The gut microbiome is not just a collection of bacteria, but an active system that interacts with enzymes, the epithelium, and even the brain. In this article, we will consider the role of the microbiome precisely from the perspective of <strong data-start=\"529\" data-end=\"553\">digestive mechanisms<\/strong>, which it provides.<\/p>\n<h2 data-start=\"576\" data-end=\"622\">The main stages of microbiome participation in digestion<\/h2>\n<h3 data-start=\"624\" data-end=\"667\">1. <strong data-start=\"631\" data-end=\"667\">Help with fiber breakdown<\/strong><\/h3>\n<p data-start=\"669\" data-end=\"1027\">In the small intestine, digestion of dietary fiber almost does not occur, because humans lack the enzymes for this process. The colonic microbiome, in particular bacteria of the genera <em data-start=\"853\" data-end=\"866\">Bacteroides<\/em> \u0456 <em data-start=\"869\" data-end=\"881\">Firmicutes<\/em>. They break down cellulose, hemicellulose, and pectins to form short-chain fatty acids (SCFAs), which provide energy for intestinal cells.<\/p>\n<h3 data-start=\"1029\" data-end=\"1071\">2. <strong data-start=\"1036\" data-end=\"1071\">Synthesis of nutrients and metabolites<\/strong><\/h3>\n<p data-start=\"1073\" data-end=\"1189\">Some of the vitamins and compounds that the body uses are formed precisely as a result of microbial activity. These include:<\/p>\n<ul data-start=\"1191\" data-end=\"1253\">\n<li data-start=\"1191\" data-end=\"1202\">\n<p data-start=\"1193\" data-end=\"1202\">Vitamin K<\/p>\n<\/li>\n<li data-start=\"1203\" data-end=\"1216\">\n<p data-start=\"1205\" data-end=\"1216\">Biotin (B7)<\/p>\n<\/li>\n<li data-start=\"1217\" data-end=\"1235\">\n<p data-start=\"1219\" data-end=\"1235\">B vitamins<\/p>\n<\/li>\n<li data-start=\"1236\" data-end=\"1253\">\n<p data-start=\"1238\" data-end=\"1253\">Folic acid<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"1255\" data-end=\"1299\">3. <strong data-start=\"1262\" data-end=\"1299\">Regulation of acidity and enzymes<\/strong><\/h3>\n<p data-start=\"1301\" data-end=\"1476\"><a href=\"https:\/\/medilab.km.ua\/en\/how-bacteria-affect-the-intestinal-microbiome-and-why-it-is-important-to-maintain-its-balance\/\">Microbiome<\/a> affects the acid-base balance in the intestine. Some bacteria change the pH level, creating optimal conditions for the action of intestinal enzymes, such as amylase or lipase.<\/p>\n<p data-start=\"1301\" data-end=\"1476\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-9720\" src=\"https:\/\/medilab.km.ua\/wp-content\/themes\/woodmart\/images\/lazy.svg\" data-src=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom.jpg\" alt=\"Microbiome enzyme activity graph\" width=\"1200\" height=\"675\" srcset=\"\" data-srcset=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom.jpg 1200w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom-150x84.jpg 150w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom-600x338.jpg 600w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom-300x169.jpg 300w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom-1024x576.jpg 1024w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/05\/predstavlenie-mikroorganizmov-s-iogurtom-768x432.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<h2 data-start=\"1478\" data-end=\"1522\">Why digestion is disrupted without a microbiome<\/h2>\n<p data-start=\"1524\" data-end=\"1682\">In dysbiosis, when the balance of microorganisms is disrupted (for example, due to antibiotics or a low-fiber diet), a number of negative changes occur:<\/p>\n<ul data-start=\"1684\" data-end=\"1942\">\n<li data-start=\"1684\" data-end=\"1765\">\n<p data-start=\"1686\" data-end=\"1765\">The formation of CFA decreases \u2192 the epithelium is poorly nourished \u2192 inflammation of the intestinal wall<\/p>\n<\/li>\n<li data-start=\"1766\" data-end=\"1831\">\n<p data-start=\"1768\" data-end=\"1831\">The absorption of trace elements (iron, magnesium, calcium) deteriorates.<\/p>\n<\/li>\n<li data-start=\"1832\" data-end=\"1892\">\n<p data-start=\"1834\" data-end=\"1892\">Increased permeability of the intestinal barrier (leaky gut syndrome)<\/p>\n<\/li>\n<li data-start=\"1893\" data-end=\"1942\">\n<p data-start=\"1895\" data-end=\"1942\">Conditionally pathogenic bacteria may become active<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1944\" data-end=\"2045\">All this disrupts not only digestion, but also the body&#039;s overall metabolism, affecting immunity and mood.<\/p>\n<h2 data-start=\"2047\" data-end=\"2072\">Example from the study<\/h2>\n<p data-start=\"2074\" data-end=\"2391\">According to the publication <em data-start=\"2095\" data-end=\"2123\">Nature Microbiology (2023)<\/em>, in a group of people with IBS (irritable bowel syndrome), a decrease in the level of <em data-start=\"2206\" data-end=\"2236\">Faecalibacterium prausnitzii<\/em> \u2014 one of the key producers of butyrate. The control group with high levels of this species had better peristalsis and fewer symptoms of flatulence.<\/p>\n<h2 data-start=\"2393\" data-end=\"2423\">What modern science recommends<\/h2>\n<p data-start=\"2425\" data-end=\"2668\">International medical institutions, in particular <strong data-start=\"2464\" data-end=\"2472\">WHO<\/strong> \u0456 <strong data-start=\"2475\" data-end=\"2510\">Harvard School of Public Health<\/strong>, call for a personalized approach: microbiome research (metagenomics) helps select nutrition and even <a href=\"https:\/\/medilab.km.ua\/en\/probiotics-their-importance-for-health-i-have-seen-and-the-rules-of-reception\/\">probiotics<\/a> for individual needs.<\/p>\n<h2 data-start=\"2670\" data-end=\"2684\">Infographics<\/h2>\n<div class=\"_tableContainer_16hzy_1\">\n<div class=\"_tableWrapper_16hzy_14 group flex w-fit flex-col-reverse\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"2686\" data-end=\"3360\">\n<thead data-start=\"2686\" data-end=\"2796\">\n<tr data-start=\"2686\" data-end=\"2796\">\n<th data-start=\"2686\" data-end=\"2715\" data-col-size=\"sm\">Microbiome function<\/th>\n<th data-start=\"2715\" data-end=\"2746\" data-col-size=\"sm\">Example of bacteria<\/th>\n<th data-start=\"2746\" data-end=\"2796\" data-col-size=\"sm\">Benefits for digestion<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"2909\" data-end=\"3360\">\n<tr data-start=\"2909\" data-end=\"3020\">\n<td data-start=\"2909\" data-end=\"2938\" data-col-size=\"sm\">Fiber fermentation<\/td>\n<td data-start=\"2938\" data-end=\"2970\" data-col-size=\"sm\"><em data-start=\"2940\" data-end=\"2953\">Bacteroides<\/em>, <em data-start=\"2955\" data-end=\"2969\">Ruminococcus<\/em><\/td>\n<td data-start=\"2970\" data-end=\"3020\" data-col-size=\"sm\">Synthesis of CFA, nutrition of the intestinal epithelium<\/td>\n<\/tr>\n<tr data-start=\"3021\" data-end=\"3135\">\n<td data-start=\"3021\" data-end=\"3050\" data-col-size=\"sm\">Vitamin synthesis<\/td>\n<td data-start=\"3050\" data-end=\"3087\" data-col-size=\"sm\"><em data-start=\"3052\" data-end=\"3067\">Lactobacillus<\/em>, <em data-start=\"3069\" data-end=\"3086\">Bifidobacterium<\/em><\/td>\n<td data-start=\"3087\" data-end=\"3135\" data-col-size=\"sm\">Vitamins B12, K, folic acid<\/td>\n<\/tr>\n<tr data-start=\"3136\" data-end=\"3248\">\n<td data-start=\"3136\" data-end=\"3165\" data-col-size=\"sm\">Modulation of inflammation<\/td>\n<td data-start=\"3165\" data-end=\"3201\" data-col-size=\"sm\"><em data-start=\"3167\" data-end=\"3185\">Faecalibacterium<\/em>, <em data-start=\"3187\" data-end=\"3200\">Akkermansia<\/em><\/td>\n<td data-start=\"3201\" data-end=\"3248\" data-col-size=\"sm\">Reducing inflammation in the intestinal wall<\/td>\n<\/tr>\n<tr data-start=\"3249\" data-end=\"3360\">\n<td data-start=\"3249\" data-end=\"3278\" data-col-size=\"sm\">Barrier function<\/td>\n<td data-start=\"3278\" data-end=\"3311\" data-col-size=\"sm\"><em data-start=\"3280\" data-end=\"3291\">Roseburia<\/em>, <em data-start=\"3293\" data-end=\"3306\">Clostridium<\/em><\/td>\n<td data-start=\"3311\" data-end=\"3360\" data-col-size=\"sm\">Reducing intestinal permeability to toxins<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\">\n<div class=\"absolute end-0 flex items-end\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p data-start=\"3362\" data-end=\"3651\">Building and maintaining a healthy microbiome is not a temporary solution, but a long-term strategy. A diet rich in fiber (fruits, vegetables, grains), regular physical activity, and moderate use of antibiotics are key to maintaining a balanced microflora and efficient digestion.<\/p>","protected":false},"excerpt":{"rendered":"<p>The microorganisms that live inside us may seem foreign, but without them, digestion would be incomplete. The gut microbiome is not<\/p>","protected":false},"author":627,"featured_media":9719,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9718","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/9718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=9718"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/9718\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/9719"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=9718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=9718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=9718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}