{"id":9849,"date":"2025-06-12T03:14:14","date_gmt":"2025-06-12T00:14:14","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=9849"},"modified":"2026-04-20T18:53:42","modified_gmt":"2026-04-20T15:53:42","slug":"chronic-inflammation-is-not-just-exhaustion-it-is-also-known-as-exhaustion","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/chronic-inflammation-is-not-just-exhaustion-it-is-also-known-as-exhaustion\/","title":{"rendered":"CHRONIC FATIGUE: HOW TO RECOGNIZE THAT IT&#039;S NOT JUST EXHAUST"},"content":{"rendered":"<p data-start=\"120\" data-end=\"153\"><strong data-start=\"120\" data-end=\"153\">A condition that does not go away after sleep<\/strong><\/p>\n<p data-start=\"155\" data-end=\"438\">When, even after a full night&#039;s rest, you wake up feeling completely exhausted, it may not be just overwork. The state of chronic fatigue is not a fiction. It is a serious functional disorder that affects a person&#039;s physical, psychological, and even social health.<\/p>\n<p data-start=\"440\" data-end=\"467\"><strong data-start=\"440\" data-end=\"467\">What is chronic fatigue?<\/strong><\/p>\n<p data-start=\"469\" data-end=\"817\">Chronic fatigue syndrome (CFS or ME\/CFS) is a multifactorial disorder that lasts for more than six months, significantly limits activity, and is not associated with other diseases. In 2023, the US National Institutes of Health confirmed that CFS is neuroimmune in nature, and therefore requires an integrated approach to diagnosis and treatment.<\/p>\n<p data-start=\"819\" data-end=\"853\"><strong data-start=\"819\" data-end=\"853\">Causes that trigger the syndrome<\/strong><\/p>\n<p data-start=\"855\" data-end=\"919\">There may be several reasons, but most often it is a combination of factors:<\/p>\n<ul data-start=\"921\" data-end=\"1197\">\n<li data-start=\"921\" data-end=\"963\">\n<p data-start=\"923\" data-end=\"963\">Infections (Epstein-Barr, CMV, SARS-CoV-2)<\/p>\n<\/li>\n<li data-start=\"964\" data-end=\"1018\">\n<p data-start=\"966\" data-end=\"1018\">Hormonal disorders (thyroid, cortisol)<\/p>\n<\/li>\n<li data-start=\"1019\" data-end=\"1048\">\n<p data-start=\"1021\" data-end=\"1048\">Immunological instability<\/p>\n<\/li>\n<li data-start=\"1049\" data-end=\"1087\">\n<p data-start=\"1051\" data-end=\"1087\">Disruption of the intestinal microbiota<\/p>\n<\/li>\n<li data-start=\"1088\" data-end=\"1142\">\n<p data-start=\"1090\" data-end=\"1142\"><a href=\"https:\/\/medilab.km.ua\/en\/vitamin-deficiency-causes-symptoms-and-ways-to-restore-balance\/\">Vitamin deficiency<\/a> and trace elements (<a href=\"https:\/\/medilab.km.ua\/en\/vitamin-b12-deficiency-is-a-must-to-check-what-it-means-to-have-a-balanced-diet\/\">B12<\/a>, D, ferritin)<\/p>\n<\/li>\n<li data-start=\"1143\" data-end=\"1197\">\n<p data-start=\"1145\" data-end=\"1197\">Prolonged psycho-emotional stress or emotional burnout<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1199\" data-end=\"1224\"><strong data-start=\"1199\" data-end=\"1224\">Why are tests important?<\/strong><\/p>\n<p data-start=\"1226\" data-end=\"1433\">Unlike normal fatigue, which resolves with rest, chronic fatigue does not respond to simple solutions. It is important to rule out other conditions (anemia, hypothyroidism, depression, infections) before making this diagnosis.<\/p>\n<p data-start=\"1435\" data-end=\"1488\"><strong data-start=\"1435\" data-end=\"1488\">MANDATORY ANALYSES IF CHRONIC FATIGUE IS SUSPECTED<\/strong><\/p>\n<div class=\"_tableContainer_16hzy_1\">\n<div class=\"_tableWrapper_16hzy_14 group flex w-fit flex-col-reverse\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"1490\" data-end=\"2401\">\n<thead data-start=\"1490\" data-end=\"1604\">\n<tr data-start=\"1490\" data-end=\"1604\">\n<th data-start=\"1490\" data-end=\"1522\" data-col-size=\"sm\">Analysis name<\/th>\n<th data-start=\"1522\" data-end=\"1563\" data-col-size=\"sm\">What does it show?<\/th>\n<th data-start=\"1563\" data-end=\"1604\" data-col-size=\"sm\">What is it for?<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"1719\" data-end=\"2401\">\n<tr data-start=\"1719\" data-end=\"1832\">\n<td data-start=\"1719\" data-end=\"1750\" data-col-size=\"sm\"><a class=\"wpil_keyword_link\" href=\"https:\/\/medilab.km.ua\/en\/analysis\/hematological-panel\/zagalnyj-rozgornutyj-analiz-krovi-avtomatychnyj-analyzer-wbc-lym-mid-grn-lym-mid-grn-rbc-hb-hct-mcv-mch-mchc-rdw-plt-pct-mpv-pdw-3-histogramy-wbc-rbc-plt-shoe-ruchnyj-pidrahunok-lejkotsytarnoyi-fo\/\"   title=\"Complete blood count + Complete blood count (manual count): WBC, Lym, Mid, Grn, Lym %, Mid %, Grn %, RBC, Hb, Hct, MCV, MCH, MCHC, RDW, Plt, Pct, MPV, PDW, 3 histograms (WBC, RBC, PLT). ESR + manual count of complete blood count)\" data-wpil-keyword-link=\"linked\"  data-wpil-monitor-id=\"349\">Complete blood count<\/a><\/td>\n<td data-start=\"1750\" data-end=\"1791\" data-col-size=\"sm\">Inflammation, anemia<\/td>\n<td data-start=\"1791\" data-end=\"1832\" data-col-size=\"sm\">Rule out infections and anemia<\/td>\n<\/tr>\n<tr data-start=\"1833\" data-end=\"1946\">\n<td data-start=\"1833\" data-end=\"1864\" data-col-size=\"sm\">Ferritin, <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/biochemical-blood-tests\/anemia-diagnosis\/iron\/\">iron<\/a><\/td>\n<td data-start=\"1864\" data-end=\"1905\" data-col-size=\"sm\">Iron stores<\/td>\n<td data-start=\"1905\" data-end=\"1946\" data-col-size=\"sm\">Important for muscle weakness<\/td>\n<\/tr>\n<tr data-start=\"1947\" data-end=\"2060\">\n<td data-start=\"1947\" data-end=\"1978\" data-col-size=\"sm\">TSH, T3, T4<\/td>\n<td data-start=\"1978\" data-end=\"2019\" data-col-size=\"sm\">Thyroid function<\/td>\n<td data-start=\"2019\" data-end=\"2060\" data-col-size=\"sm\">Detection of hypo\/hyperthyroidism<\/td>\n<\/tr>\n<tr data-start=\"2061\" data-end=\"2173\">\n<td data-start=\"2061\" data-end=\"2091\" data-col-size=\"sm\"><a href=\"https:\/\/medilab.km.ua\/en\/analysis\/hormonal-panel\/gipotalamo-gipofizarno-nadnyrnykova-systema\/cortisol\/\">Cortisol<\/a><\/td>\n<td data-start=\"2091\" data-end=\"2132\" data-col-size=\"sm\">Adrenal gland condition<\/td>\n<td data-start=\"2132\" data-end=\"2173\" data-col-size=\"sm\">Stress response assessment<\/td>\n<\/tr>\n<tr data-start=\"2174\" data-end=\"2287\">\n<td data-start=\"2174\" data-end=\"2205\" data-col-size=\"sm\">Vitamin B12, folic acid<\/td>\n<td data-start=\"2205\" data-end=\"2246\" data-col-size=\"sm\">Neuromuscular tone<\/td>\n<td data-start=\"2246\" data-end=\"2287\" data-col-size=\"sm\">Identifying deficits for correction<\/td>\n<\/tr>\n<tr data-start=\"2288\" data-end=\"2401\">\n<td data-start=\"2288\" data-end=\"2319\" data-col-size=\"sm\"><a href=\"https:\/\/medilab.km.ua\/en\/analysis\/biochemical-blood-tests\/cardio-rev-motorology-panel\/c-reactive-protein-quantitative-determination-of-c-reactive-protein-crp\/\">CRP<\/a>, ESR<\/td>\n<td data-start=\"2319\" data-end=\"2360\" data-col-size=\"sm\">Inflammatory processes<\/td>\n<td data-start=\"2360\" data-end=\"2401\" data-col-size=\"sm\">In chronic subclinical inflammation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\">\n<div class=\"absolute end-0 flex items-end\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p data-start=\"2403\" data-end=\"2437\"><strong data-start=\"2403\" data-end=\"2437\">Research: What the Science Says<\/strong><\/p>\n<p data-start=\"2439\" data-end=\"2728\">2021 study (<em data-start=\"2462\" data-end=\"2485\">Nature Communications<\/em>) found decreased mitochondrial activity and impaired cellular energy metabolism in patients with ME\/CFS. Other publications, for example in <em data-start=\"2633\" data-end=\"2658\">Frontiers in Immunology<\/em>, prove a change in the level of pro-inflammatory cytokines in the blood of such patients.<\/p>\n<p data-start=\"2439\" data-end=\"2728\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-9851\" src=\"https:\/\/medilab.km.ua\/wp-content\/themes\/woodmart\/images\/lazy.svg\" data-src=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom.jpg\" alt=\"Table with tests for chronic fatigue\" width=\"1200\" height=\"801\" srcset=\"\" data-srcset=\"https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom.jpg 1200w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom-150x100.jpg 150w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom-600x401.jpg 600w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom-300x200.jpg 300w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom-1024x684.jpg 1024w, https:\/\/medilab.km.ua\/wp-content\/uploads\/2025\/06\/lekarstva-so-spricem-na-serom-768x513.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p data-start=\"2730\" data-end=\"2750\"><strong data-start=\"2730\" data-end=\"2750\">Support methods<\/strong><\/p>\n<p data-start=\"2752\" data-end=\"2811\">Chronic fatigue is not treated with a \u00absingle pill.\u00bb Instead:<\/p>\n<ul data-start=\"2813\" data-end=\"3118\">\n<li data-start=\"2813\" data-end=\"2860\">\n<p data-start=\"2815\" data-end=\"2860\">Psychotherapy (cognitive behavioral therapy)<\/p>\n<\/li>\n<li data-start=\"2861\" data-end=\"2907\">\n<p data-start=\"2863\" data-end=\"2907\">Gradual physical activity (graded)<\/p>\n<\/li>\n<li data-start=\"2908\" data-end=\"2959\">\n<p data-start=\"2910\" data-end=\"2959\">A diet rich in protein and antioxidants<\/p>\n<\/li>\n<li data-start=\"2960\" data-end=\"3010\">\n<p data-start=\"2962\" data-end=\"3010\">Sleep normalization (melatonin, relaxation techniques)<\/p>\n<\/li>\n<li data-start=\"3011\" data-end=\"3066\">\n<p data-start=\"3013\" data-end=\"3066\">Drugs for correction of deficiencies (based on tests)<\/p>\n<\/li>\n<li data-start=\"3067\" data-end=\"3118\">\n<p data-start=\"3069\" data-end=\"3118\">Phytotherapy (rhodiola rosea, ashwagandha, lemon balm)<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"3120\" data-end=\"3171\"><strong data-start=\"3120\" data-end=\"3171\">What to do if you suspect you have chronic fatigue<\/strong><\/p>\n<ol data-start=\"3173\" data-end=\"3406\">\n<li data-start=\"3173\" data-end=\"3220\">\n<p data-start=\"3176\" data-end=\"3220\">Consult a therapist or family doctor<\/p>\n<\/li>\n<li data-start=\"3221\" data-end=\"3265\">\n<p data-start=\"3224\" data-end=\"3265\">Get an advanced laboratory examination<\/p>\n<\/li>\n<li data-start=\"3266\" data-end=\"3313\">\n<p data-start=\"3269\" data-end=\"3313\">Avoid overloading even on \u00abgood\u00bb days<\/p>\n<\/li>\n<li data-start=\"3314\" data-end=\"3356\">\n<p data-start=\"3317\" data-end=\"3356\">Keep a diary of your activity and symptoms<\/p>\n<\/li>\n<li data-start=\"3357\" data-end=\"3406\">\n<p data-start=\"3360\" data-end=\"3406\">Gradually, without rushing, restore the rhythm of life<\/p>\n<\/li>\n<\/ol>\n<p>The aforementioned syndrome still remains a challenge for medicine. However, timely detection and support help significantly improve the quality of life of people who encounter it.<\/p>","protected":false},"excerpt":{"rendered":"<p>A condition that doesn&#039;t go away after sleep When even after a full night&#039;s rest you wake up feeling completely exhausted - this is<\/p>","protected":false},"author":627,"featured_media":9850,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/9849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/users\/627"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=9849"}],"version-history":[{"count":0,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/posts\/9849\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/9850"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=9849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/categories?post=9849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/tags?post=9849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}