{"id":9853,"date":"2025-06-11T03:15:58","date_gmt":"2025-06-11T00:15:58","guid":{"rendered":"https:\/\/medilab.km.ua\/?p=9853"},"modified":"2026-04-20T18:53:43","modified_gmt":"2026-04-20T15:53:43","slug":"angioedema-is-an-emergency-condition-that-should-not-be-ignored","status":"publish","type":"post","link":"https:\/\/medilab.km.ua\/en\/angioedema-is-an-emergency-condition-that-should-not-be-ignored\/","title":{"rendered":"Angioedema: An emergency that should not be ignored"},"content":{"rendered":"
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\n 4.9\/5 - (590 votes) <\/div>\n <\/div>\n

What is angioedema?<\/strong>
Angioedema (ANN), or angioedema, is a sudden, profound swelling of the skin, subcutaneous tissue, mucous membranes, or larynx, usually caused by an allergic or pseudoallergic reaction. This condition is considered an emergency because it can cause life-threatening airway obstruction.<\/p>\n

Developmental mechanisms: how and why edema occurs<\/strong><\/h3>\n

Angioedema occurs due to increased vascular wall permeability caused by inflammatory mediators. The main pathogenetic mechanisms are:<\/p>\n

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  • \n

    Histamine pathway<\/strong> \u2014 a reaction to allergens (foods, medications, insect bites), as a rule, is accompanied by hives.<\/p>\n<\/li>\n

  • \n

    Bradykinin pathway<\/strong> \u2014 characteristic of hereditary or acquired forms of ANN, associated with C1-esterase inhibitor deficiency.<\/p>\n<\/li>\n

  • \n

    Idiopathic mechanism<\/strong> \u2014 when the cause is not precisely established.<\/p>\n<\/li>\n<\/ul>\n

    Main symptoms of angioedema<\/strong><\/h3>\n
      \n
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      Fast growing localized swelling<\/strong> (face, lips, eyelids, tongue, larynx, genitals)<\/p>\n<\/li>\n

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      Presence of pain or burning sensation<\/strong>, but usually no itching<\/strong><\/p>\n<\/li>\n

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      Dyspnea<\/strong>, difficulty swallowing or voice changes (with laryngeal edema)<\/p>\n<\/li>\n

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      In hereditary form - repeated episodes<\/strong>, that occur without an obvious allergen<\/p>\n<\/li>\n<\/ul>\n

      \"Table<\/p>\n

      The importance of laboratory diagnostics<\/strong><\/h3>\n

      Correct diagnosis is critical, as the treatment of histamine and bradykinin ANN is radically different.<\/p>\n

      Table of tests for different types of angioedema<\/strong><\/p>\n

      \n
      \n\n\n\n\n\n\n\n\n
      Type of ANN<\/th>\nC1 inhibitor<\/th>\nC4<\/th>\nIgE<\/th>\nFrequency<\/th>\n<\/tr>\n<\/thead>\n
      Allergic<\/td>\nNorm<\/td>\nNorm<\/td>\nIncreased<\/td>\nFrequent<\/td>\n<\/tr>\n
      Hereditary<\/td>\nReduced<\/td>\nReduced<\/td>\nNorm<\/td>\nRare<\/td>\n<\/tr>\n
      Medicated<\/td>\nNorm<\/td>\nCan be reduced<\/td>\nNorm<\/td>\nOccurs<\/td>\n<\/tr>\n
      Idiopathic<\/td>\nNorm<\/td>\nNorm<\/td>\nNorm<\/td>\nNot installed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

      Emergency care for acute edema<\/strong><\/h3>\n
        \n
      • \n

        Antihistamines<\/strong> (loratadine, cetirizine)<\/p>\n<\/li>\n

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        Glucocorticosteroids<\/strong> (prednisolone, dexamethasone)<\/p>\n<\/li>\n

      • \n

        Adrenaline (epinephrine)<\/strong> \u2014 at risk of anaphylaxis<\/p>\n<\/li>\n

      • \n

        Bradykinin inhibitors<\/strong> (icatibant) or plasma<\/strong> \u2014 in the case of hereditary ANN<\/p>\n<\/li>\n<\/ul>\n

        Research and clinical recommendations<\/strong><\/h3>\n

        In the report World Allergy Organization (WAO)<\/em> (2022) noted that up to 30% cases of ANN are non-allergic in nature. It was also emphasized that hereditary forms are often not diagnosed in time, which creates a risk of fatal airway obstruction. That is why in many countries it is recommended to carry an emergency first aid kit.<\/p>\n

        Angioedema is not just a cosmetic problem. In some cases, it is a life-threatening condition. Early diagnosis, access to emergency treatment, and understanding the different mechanisms of development can save lives.<\/p>","protected":false},"excerpt":{"rendered":"

        What is angioedema? Angioedema (ANN), or angioedema, is a sudden, deep swelling of the skin, subcutaneous tissue, mucous membranes, or<\/p>","protected":false},"author":627,"featured_media":9854,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\n\u0410\u043d\u0433\u0456\u043e\u043d\u0435\u0432\u0440\u043e\u0442\u0438\u0447\u043d\u0438\u0439 \u043d\u0430\u0431\u0440\u044f\u043a: \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u0438, \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0442\u0430 \u043b\u0456\u043a\u0443\u0432\u0430\u043d\u043d\u044f<\/title>\n<meta name=\"description\" content=\"\u0410\u043d\u0433\u0456\u043e\u043d\u0435\u0432\u0440\u043e\u0442\u0438\u0447\u043d\u0438\u0439 \u043d\u0430\u0431\u0440\u044f\u043a 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\u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0457 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438, \u043a\u043b\u0456\u043d\u0456\u0447\u043d\u043e\u0457 \u0431\u0456\u043e\u0445\u0456\u043c\u0456\u0457 \u0442\u0430 \u0456\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0456\u0457. \u041c\u0430\u0454 \u043f\u043e\u043d\u0430\u0434 45 \u0440\u043e\u043a\u0456\u0432 \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u043d\u043e\u0433\u043e \u0434\u043e\u0441\u0432\u0456\u0434\u0443 \u0432 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0456 \u0442\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0456\u0439 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0446\u0456. \u0417 2007 \u0440\u043e\u043a\u0443 \u2014 \u0437\u0430\u0441\u043d\u043e\u0432\u043d\u0438\u043a \u0456 \u043a\u0435\u0440\u0456\u0432\u043d\u0438\u043a \u0422\u041e\u0412 \u00ab\u041c\u0435\u0434\u0456 \u041b\u0430\u0431 \u041f\u043b\u044e\u0441\u00bb. \u041f\u0440\u043e\u0444\u0435\u0441\u0456\u0439\u043d\u0438\u0439 \u0448\u043b\u044f\u0445 \u0440\u043e\u0437\u043f\u043e\u0447\u0430\u043b\u0430 \u0437 \u0440\u043e\u0431\u043e\u0442\u0438 \u043c\u0435\u0434\u0438\u0447\u043d\u043e\u044e \u0441\u0435\u0441\u0442\u0440\u043e\u044e, \u043d\u0430\u0434\u0430\u043b\u0456 \u043f\u0440\u0430\u0446\u044e\u0432\u0430\u043b\u0430 \u043f\u043e\u043c\u0456\u0447\u043d\u0438\u043a\u043e\u043c \u0435\u043f\u0456\u0434\u0435\u043c\u0456\u043e\u043b\u043e\u0433\u0430 \u0442\u0430 \u043b\u0456\u043a\u0430\u0440\u0435\u043c-\u043b\u0430\u0431\u043e\u0440\u0430\u043d\u0442\u043e\u043c. \u0423 1987\u20132007 \u0440\u043e\u043a\u0430\u0445 \u043e\u0447\u043e\u043b\u044e\u0432\u0430\u043b\u0430 \u0446\u0435\u043d\u0442\u0440\u0430\u043b\u0456\u0437\u043e\u0432\u0430\u043d\u0443 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0443 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0456\u044e. \u041e\u0441\u0432\u0456\u0442\u0430 \u0442\u0430 \u0441\u043f\u0435\u0446\u0456\u0430\u043b\u0456\u0437\u0430\u0446\u0456\u0457 \u2022 1979 \u0440. \u2014 \u0425\u043c\u0435\u043b\u044c\u043d\u0438\u0446\u044c\u043a\u0435 \u0431\u0430\u0437\u043e\u0432\u0435 \u043c\u0435\u0434\u0438\u0447\u043d\u0435 \u0443\u0447\u0438\u043b\u0438\u0449\u0435, \u0444\u0435\u043b\u044c\u0434\u0448\u0435\u0440 \u2022 1986 \u0440. \u2014 \u041e\u0434\u0435\u0441\u044c\u043a\u0438\u0439 \u0434\u0435\u0440\u0436\u0430\u0432\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c. \u0406.\u0406. \u041c\u0435\u0447\u043d\u0456\u043a\u043e\u0432\u0430, \u0431\u0456\u043e\u043b\u043e\u0433 \u2022 2001 \u0440. \u2014 \u043a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0430 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u041d\u041c\u0410\u041f\u041e \u0456\u043c. \u041f.\u041b. \u0428\u0443\u043f\u0438\u043a\u0430 \u2022 2008 \u0440. \u2014 \u041f\u041b\u0420-\u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0456\u043d\u0444\u0435\u043a\u0446\u0456\u0439\u043d\u0438\u0445 \u0445\u0432\u043e\u0440\u043e\u0431, \u0406\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0435\u043f\u0456\u0434\u0435\u043c\u0456\u043e\u043b\u043e\u0433\u0456\u0457 \u0456\u043c. \u041b.\u0412. \u0413\u0440\u043e\u043c\u0430\u0448\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u2022 2010, 2015, 2021 \u0440\u0440. \u2014 \u043e\u0440\u0433\u0430\u043d\u0456\u0437\u0430\u0446\u0456\u044f \u0456 \u0443\u043f\u0440\u0430\u0432\u043b\u0456\u043d\u043d\u044f \u043e\u0445\u043e\u0440\u043e\u043d\u043e\u044e \u0437\u0434\u043e\u0440\u043e\u0432\u2019\u044f \u2022 2017 \u0440. \u2014 \u043a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0430 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0430 \u0432\u0456\u0439\u0441\u044c\u043a\u043e\u0432\u043e-\u043c\u0435\u0434\u0438\u0447\u043d\u0430 \u0430\u043a\u0430\u0434\u0435\u043c\u0456\u044f \u2022 2017 \u0440. \u2014 \u043a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u0431\u0456\u043e\u0445\u0456\u043c\u0456\u044f, \u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0430 \u0432\u0456\u0439\u0441\u044c\u043a\u043e\u0432\u043e-\u043c\u0435\u0434\u0438\u0447\u043d\u0430 \u0430\u043a\u0430\u0434\u0435\u043c\u0456\u044f \u2022 2018 \u0440. \u2014 \u043a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u0456\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0456\u044f, \u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0430 \u0432\u0456\u0439\u0441\u044c\u043a\u043e\u0432\u043e-\u043c\u0435\u0434\u0438\u0447\u043d\u0430 \u0430\u043a\u0430\u0434\u0435\u043c\u0456\u044f \u2022 2025 \u0440. \u2014 \u0430\u043a\u0442\u0443\u0430\u043b\u044c\u043d\u0456 \u043f\u0438\u0442\u0430\u043d\u043d\u044f \u0441\u0443\u0447\u0430\u0441\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438 \u0442\u0430 \u0444\u0430\u0440\u043c\u0430\u0446\u0456\u0457, \u0425\u0430\u0440\u043a\u0456\u0432\u0441\u044c\u043a\u0438\u0439 \u043f\u043e\u043b\u0456\u0442\u0435\u0445\u043d\u0456\u0447\u043d\u0438\u0439 \u0456\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0414\u043e\u0441\u0432\u0456\u0434 \u0440\u043e\u0431\u043e\u0442\u0438 \u2022 1979\u20131982 \u0440\u0440. \u2014 \u043c\u0435\u0434\u0438\u0447\u043d\u0430 \u0441\u0435\u0441\u0442\u0440\u0430 \u0441\u0442\u0430\u0446\u0456\u043e\u043d\u0430\u0440\u0443 \u2022 1982\u20131986 \u0440\u0440. \u2014 \u043f\u043e\u043c\u0456\u0447\u043d\u0438\u043a \u0435\u043f\u0456\u0434\u0435\u043c\u0456\u043e\u043b\u043e\u0433\u0430 \u2022 1986\u20131987 \u0440\u0440. \u2014 \u043b\u0456\u043a\u0430\u0440-\u043b\u0430\u0431\u043e\u0440\u0430\u043d\u0442 \u2022 1987\u20132007 \u0440\u0440. \u2014 \u0437\u0430\u0432\u0456\u0434\u0443\u0432\u0430\u0447 \u0446\u0435\u043d\u0442\u0440\u0430\u043b\u0456\u0437\u043e\u0432\u0430\u043d\u043e\u0457 \u0441\u0435\u0440\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u043e\u0457 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0456\u0457 \u2022 \u0417 2007 \u0440. \u2014 \u0434\u0438\u0440\u0435\u043a\u0442\u043e\u0440 \u0422\u041e\u0412 \u00ab\u041c\u0435\u0434\u0456 \u041b\u0430\u0431 \u041f\u043b\u044e\u0441\u00bb \u041a\u043b\u044e\u0447\u043e\u0432\u0456 \u043a\u043e\u043c\u043f\u0435\u0442\u0435\u043d\u0446\u0456\u0457 \u041e\u0440\u0433\u0430\u043d\u0456\u0437\u0430\u0446\u0456\u044f \u0442\u0430 \u0443\u043f\u0440\u0430\u0432\u043b\u0456\u043d\u043d\u044f \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u043c\u0438 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0456\u044f\u043c\u0438, \u0432\u043f\u0440\u043e\u0432\u0430\u0434\u0436\u0435\u043d\u043d\u044f \u0441\u0443\u0447\u0430\u0441\u043d\u0438\u0445 \u043c\u0435\u0442\u043e\u0434\u0456\u0432 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Specialist in clinical laboratory diagnostics, clinical biochemistry and immunology. Has over 45 years of practical experience in medicine and laboratory diagnostics. Since 2007, he has been the founder and head of Medi Lab Plus LLC. She began her professional career as a nurse, later worked as an assistant epidemiologist and laboratory assistant. In 1987\u20132007, she headed a centralized serological laboratory. Education and specializations \u2022 1979 \u2014 Khmelnytskyi Basic Medical School, paramedic \u2022 1986 \u2014 Odessa State University named after I.I. Mechnikov, biologist \u2022 2001 \u2014 clinical laboratory diagnostics, NMAPE named after P.L. Shupyk \u2022 2008 \u2014 PCR diagnostics of infectious diseases, Institute of Epidemiology named after L.V. 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