{"id":10428,"date":"2025-09-19T07:29:15","date_gmt":"2025-09-19T04:29:15","guid":{"rendered":"https:\/\/medilab.km.ua\/?post_type=product&p=10428"},"modified":"2025-10-01T12:59:50","modified_gmt":"2025-10-01T09:59:50","slug":"antineutrophil-cytoplasmic-antibodies-to-protease-3-anti-pr3-c-anca-igg","status":"publish","type":"product","link":"https:\/\/medilab.km.ua\/en\/analysis\/autoimmune\/antineutrophil-cytoplasmic-antibodies-to-protease-3-anti-pr3-c-anca-igg\/","title":{"rendered":"Antineutrophil cytoplasmic proteinase 3 antibodies (anti-PR3, c-ANCA), IgG"},"content":{"rendered":"
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\n 5\/5 - (320 votes) <\/div>\n <\/div>\n

When is it appropriate to conduct research:<\/h2>\n
    \n
  • \n

    if systemic vasculitis is suspected with involvement of the upper or lower respiratory tract, kidneys, or blood vessels;<\/p>\n<\/li>\n

  • \n

    with clinical signs such as:<\/p>\n

      \n
    • \n

      long-term sinusitis, chronic rhinitis, nosebleeds;<\/p>\n<\/li>\n

    • \n

      cough, shortness of breath, hemoptysis;<\/p>\n<\/li>\n

    • \n

      proteinuria, hematuria, signs of nephritis;<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

    • \n

      to monitor the course of the disease and the effectiveness of treatment;<\/p>\n<\/li>\n

    • \n

      for differential diagnosis between different types of systemic vasculitis.<\/p>\n<\/li>\n<\/ul>\n

      Interpretation of results:<\/h2>\n
        \n
      • \n

        Positive result<\/strong>: high probability of ANCA-associated vasculitis, most often granulomatosis with polyangiitis.<\/p>\n<\/li>\n

      • \n

        Negative result<\/strong>: does not rule out the disease, especially in the early stages or with an atypical course, but reduces its likelihood.<\/p>\n<\/li>\n

      • \n

        In combination with the clinical picture and other laboratory tests, it allows for a more accurate diagnosis.<\/p>\n<\/li>\n<\/ul>\n

        Preparation for analysis:<\/h2>\n
          \n
        • \n

          no special training is required;<\/p>\n<\/li>\n

        • \n

          It is recommended to donate venous blood in the morning on an empty stomach (at least 8 hours after the last meal).<\/p>\n<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

          Anti-PR3 (c-ANCA)<\/strong> \u2013 these are IgG class autoantibodies formed against the enzyme proteinase 3<\/strong>, which is found in neutrophil granules. Their detection is an important diagnostic marker ANCA-associated systemic vasculitis<\/strong>, first of all:<\/p>\n

            \n
          • \n

            granulomatosis with polyangiitis (Wegener's granulomatosis)<\/strong>,<\/p>\n<\/li>\n

          • \n

            microscopic polyangiitis,<\/p>\n<\/li>\n

          • \n

            less often - eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).<\/p>\n<\/li>\n<\/ul>\n

            Anti-PR3 is detected in approximately 80\u201390% patients with granulomatosis with polyangiitis<\/strong>, therefore, it is one of the most specific laboratory tests for confirming the diagnosis.<\/p>","protected":false},"featured_media":10475,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[145],"product_tag":[],"class_list":{"0":"post-10428","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-autoimunologiya","8":"first","9":"instock","10":"shipping-taxable","11":"purchasable","12":"product-type-simple"},"yoast_head":"\n\u0410\u043d\u0442\u0438-PR3 (c-ANCA), IgG \u2013 \u0430\u043d\u0430\u043b\u0456\u0437 \u043d\u0430 ANCA-\u0430\u0441\u043e\u0446\u0456\u0439\u043e\u0432\u0430\u043d\u0456 \u0432\u0430\u0441\u043a\u0443\u043b\u0456\u0442\u0438 \u0443 \u041c\u0435\u0434\u0456\u043b\u0430\u0431 \u041f\u043b\u044e\u0441<\/title>\n<meta name=\"description\" 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