{"id":12378,"date":"2026-04-25T12:42:44","date_gmt":"2026-04-25T09:42:44","guid":{"rendered":"https:\/\/medilab.km.ua\/?post_type=product&#038;p=12378"},"modified":"2026-05-27T18:38:42","modified_gmt":"2026-05-27T15:38:42","slug":"lipoprotein-a-lp-a","status":"publish","type":"product","link":"https:\/\/medilab.km.ua\/en\/analysis\/biochemical-blood-tests\/lipoprotein-a-lp-a\/","title":{"rendered":"Lipoprotein (a) Lp(a)"},"content":{"rendered":"<p data-path-to-node=\"0\"><b data-path-to-node=\"0\" data-index-in-node=\"0\">Lipoprotein (a)<\/b>, or <b data-path-to-node=\"0\" data-index-in-node=\"21\">Lp(a)<\/b> is a special type of low-density lipoprotein (&quot;bad&quot; cholesterol), which is a powerful and independent genetic marker of cardiovascular disease.<\/p>\n<p data-path-to-node=\"1\">Unlike regular low-density lipoprotein (<span class=\"math-inline\" data-math=\"\u041b\u041f\u041d\u0429\" data-index-in-node=\"58\"><span class=\"katex\"><span class=\"katex-html\" aria-hidden=\"true\"><span class=\"base\"><span class=\"mord cyrillic_fallback\">LDL<\/span><\/span><\/span><\/span><\/span>), the level of Lp(a) in the blood at <b data-path-to-node=\"1\" data-index-in-node=\"89\">70\u201390% is determined by inheritance<\/b> and practically does not change throughout life under the influence of diet, exercise, or most standard medications (e.g., conventional statins).<\/p>\n<h2 data-path-to-node=\"3\">1. Why is this analysis important?<\/h2>\n<p data-path-to-node=\"4\">The structure of Lp(a) is unique: it consists of a regular LDL particle to which a special protein is attached \u2014 <b data-path-to-node=\"4\" data-index-in-node=\"111\">apolipoprotein (a)<\/b>. This combination makes Lp(a) much more dangerous than regular cholesterol for two reasons:<\/p>\n<ul data-path-to-node=\"5\">\n<li>\n<p data-path-to-node=\"5,0,0\"><b data-path-to-node=\"5,0,0\" data-index-in-node=\"0\">Atherogenicity (plaque formation):<\/b> It penetrates the walls of blood vessels more easily and oxidizes, accelerating the growth of atherosclerotic plaques.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"5,1,0\"><b data-path-to-node=\"5,1,0\" data-index-in-node=\"0\">Thrombogenicity (blood clot formation):<\/b> Structurally, the apo(a) protein is similar to plasminogen (a protein that dissolves blood clots). Lp(a) blocks the work of plasminogen, preventing the body from naturally breaking down microthrombi, which dramatically increases the risk of heart attack and stroke.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"7\">2. Indications for use<\/h2>\n<p data-path-to-node=\"8\">Lp(a) testing is not part of the standard annual checkup for everyone, but is critically important in the following cases:<\/p>\n<ul data-path-to-node=\"9\">\n<li>\n<p data-path-to-node=\"9,0,0\"><b data-path-to-node=\"9,0,0\" data-index-in-node=\"0\">Early <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/autoimmune\/immunogenetic-marker-of-susceptibility-to-the-development-of-ankylosing-spondyloarthritis-byehtyarev-39-s-disease-and-other-seronegative-spondyloarthropathies-hla-b27\/\" title=\"Immunogenetic marker of susceptibility to the development of ankylosing spondylitis (Bekhterev&#039;s disease) and other seronegative spondyloarthropathies (HLA-B27)\"  data-wpil-monitor-id=\"549\">development of cardiovascular diseases<\/a><\/b> in the patient or his\/her closest relatives (in men under 55 years of age, in women under 65 years of age).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,1,0\"><b data-path-to-node=\"9,1,0\" data-index-in-node=\"0\">Having a heart attack or stroke<\/b> in the absence of obvious risk factors (normal cholesterol levels, <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/infectious-disease-panel\/herpes-virus-infection\/human-herpesvirus-6-hnv-6-igg\/\" title=\"Human herpesvirus 6 (H\u041dV-6), IgG\"  data-wpil-monitor-id=\"545\">healthy lifestyle<\/a>, normal pressure).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,2,0\"><b data-path-to-node=\"9,2,0\" data-index-in-node=\"0\">High levels of &quot;bad&quot; cholesterol (LDL)<\/b>, which is poorly responsive to treatment with standard doses of statins.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,3,0\"><b data-path-to-node=\"9,3,0\" data-index-in-node=\"0\">Familial hypercholesterolemia<\/b> (hereditary high cholesterol).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,4,0\"><b data-path-to-node=\"9,4,0\" data-index-in-node=\"0\"><a href=\"https:\/\/medilab.km.ua\/en\/reduction-of-the-risk-of-atherosclerosis\/\" title=\"Atherosclerosis risk assessment\"  data-wpil-monitor-id=\"547\">Cardiovascular risk assessment<\/a><\/b> in patients with intermediate or high risk for a more accurate prognosis.<\/p>\n<\/li>\n<\/ul>\n<h2 data-path-to-node=\"11\">3. Reference values (norms)<\/h2>\n<p data-path-to-node=\"12\">In most laboratories, results are measured in milligrams per deciliter (<b data-path-to-node=\"12\" data-index-in-node=\"73\">mg\/dL<\/b>) or moles per liter (<b data-path-to-node=\"12\" data-index-in-node=\"99\">nmol\/l<\/b>).<\/p>\n<div class=\"horizontal-scroll-wrapper\">\n<div class=\"table-block-component\">\n<div class=\"table-block has-export-button new-table-style is-at-scroll-start is-at-scroll-end\">\n<div class=\"table-content\" data-hveid=\"0\" data-ved=\"0CAAQ3ecQahgKEwiC4vmDrNeUAxUAAAAAHQAAAAAQ9gU\">\n<table data-path-to-node=\"13\">\n<thead>\n<tr>\n<th><span data-path-to-node=\"13,0,0,0\">Risk level<\/span><\/th>\n<th><span data-path-to-node=\"13,0,1,0\">Value in mg\/dL<\/span><\/th>\n<th><span data-path-to-node=\"13,0,2,0\">Value in nmol\/L<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span data-path-to-node=\"13,1,0,0\"><b data-path-to-node=\"13,1,0,0\" data-index-in-node=\"0\">Normal (low risk)<\/b><\/span><\/td>\n<td><span data-path-to-node=\"13,1,1,0\">&lt; 30 mg\/dL<\/span><\/td>\n<td><span data-path-to-node=\"13,1,2,0\">&lt; 75 nmol\/l<\/span><\/td>\n<\/tr>\n<tr>\n<td><span data-path-to-node=\"13,2,0,0\"><b data-path-to-node=\"13,2,0,0\" data-index-in-node=\"0\">Marginal (moderate risk)<\/b><\/span><\/td>\n<td><span data-path-to-node=\"13,2,1,0\">30 \u2013 50 mg\/dL<\/span><\/td>\n<td><span data-path-to-node=\"13,2,2,0\">75 \u2013 125 nmol\/l<\/span><\/td>\n<\/tr>\n<tr>\n<td><span data-path-to-node=\"13,3,0,0\"><b data-path-to-node=\"13,3,0,0\" data-index-in-node=\"0\">High risk<\/b><\/span><\/td>\n<td><span data-path-to-node=\"13,3,1,0\">&gt; 50 mg\/dL<\/span><\/td>\n<td><span data-path-to-node=\"13,3,2,0\">&gt; 125 nmol\/L<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"table-footer hide-from-message-actions\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<blockquote data-path-to-node=\"14\">\n<p data-path-to-node=\"14,0\">\u26a0\ufe0f <b data-path-to-node=\"14,0\" data-index-in-node=\"3\">Importantly:<\/b> Since the level of Lp(a) is genetically determined, this test is usually sufficient. <b data-path-to-node=\"14,0\" data-index-in-node=\"94\">once in a lifetime<\/b>, to determine your baseline risk.<\/p>\n<\/blockquote>\n<h2 data-path-to-node=\"16\">4. Interpretation of results<\/h2>\n<h3 data-path-to-node=\"17\">What does elevated level mean?<\/h3>\n<p data-path-to-node=\"18\">A high level of Lp(a) indicates an increased susceptibility to:<\/p>\n<ul data-path-to-node=\"19\">\n<li>\n<p data-path-to-node=\"19,0,0\">Coronary heart disease (CHD) and myocardial infarction.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"19,1,0\">Ischemic stroke.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"19,2,0\">Atherosclerosis of peripheral arteries (damage to the vessels of the legs).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"19,3,0\">Stenosis (narrowing) of the aortic valve.<\/p>\n<\/li>\n<\/ul>\n<h3 data-path-to-node=\"20\">What does a reduced level mean?<\/h3>\n<p data-path-to-node=\"21\">Low values have no clinical significance and are considered normal (the lower the Lp(a) in the blood, the better for the vessels).<\/p>\n<h2 data-path-to-node=\"23\">5. What to do if Lp(a) level is high?<\/h2>\n<p data-path-to-node=\"24\">Since it is almost impossible to lower it with diet or standard statins, the strategy to protect the patient is to <b data-path-to-node=\"24\" data-index-in-node=\"109\">the strictest control of all other risk factors<\/b>:<\/p>\n<ol start=\"1\" data-path-to-node=\"25\">\n<li>\n<p data-path-to-node=\"25,0,0\"><b data-path-to-node=\"25,0,0\" data-index-in-node=\"0\">Aggressive reduction of LDL cholesterol:<\/b> If Lp(a) cannot be lowered, it is necessary to lower the usual &quot;bad&quot; cholesterol to the lowest possible values (often using a combination of statins and ezetimibe).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,1,0\"><b data-path-to-node=\"25,1,0\" data-index-in-node=\"0\">Blood pressure and sugar control:<\/b> Maintaining blood pressure within normal limits and monitoring <a href=\"https:\/\/medilab.km.ua\/en\/analysis\/biochemical-blood-tests\/diabetes-diagnosis\/blood-glucose-2\/\" title=\"Blood glucose (Glucose)\"  data-wpil-monitor-id=\"546\">blood glucose<\/a>.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,2,0\"><b data-path-to-node=\"25,2,0\" data-index-in-node=\"0\">Lifestyle:<\/b> Complete cessation of smoking (smoking with high Lp(a) increases the risk of heart attack many times over), regular physical activity, maintaining a healthy weight.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"25,3,0\"><b data-path-to-node=\"25,3,0\" data-index-in-node=\"0\">Modern therapy (as prescribed by a doctor):<\/b> Innovative drugs (PCSK9 inhibitors) can reduce Lp(a) by 20-30%, and the latest genetic drugs (siRNA), which are currently undergoing clinical trials, can reduce its level by more than 80%.<\/p>\n<\/li>\n<\/ol>\n<h2 data-path-to-node=\"26\">Preparation for analysis<\/h2>\n<ul data-path-to-node=\"27\">\n<li>\n<p data-path-to-node=\"27,0,0\">Blood is donated strictly on an empty stomach (8\u201312 hours of fasting).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,1,0\">Avoid fatty foods, alcohol, and heavy physical exertion for a day.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"27,2,0\">Do not smoke 1\u20132 hours before blood collection.<\/p>\n<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p><b data-path-to-node=\"0\" data-index-in-node=\"0\">Lipoprotein (a) [Lp(a)]<\/b> is a highly accurate genetic blood test that <a href=\"https:\/\/medilab.km.ua\/en\/mobile-accessories-for-diagnostics-as-digital-instruments-help-identify-risks-before-symptoms-appear\/\" title=\"Mobile apps for diagnostics: how digital tools help identify risks before symptoms appear\"  data-wpil-monitor-id=\"548\">reveals hidden risk<\/a> heart attack and stroke, which is not shown by normal cholesterol and which only needs to be taken once in a lifetime.<\/p>","protected":false},"featured_media":3340,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[68,77],"product_tag":[],"class_list":["post-12378","product","type-product","status-publish","has-post-thumbnail","product_cat-biohimichni-doslidzhennya-krovi","product_cat-lipidnyj-spektr-krovi","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/product\/12378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/comments?post=12378"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media\/3340"}],"wp:attachment":[{"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/media?parent=12378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/product_brand?post=12378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/product_cat?post=12378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medilab.km.ua\/en\/wp-json\/wp\/v2\/product_tag?post=12378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}