Genetics. PCR. Extended genetic marker of celiac disease HLA-DQ2.5, HLA-DQ2.2, HLA-DQ8, HLA-DRB1*04

Celiac disease is not just gluten intolerance, but a chronic autoimmune disease that occurs in genetically predisposed people. Eating foods containing gluten (wheat, barley, rye) triggers an immune response that damages the lining of the small intestine. This leads to impaired absorption of nutrients and can cause a wide range of symptoms, from digestive problems to anemia, osteoporosis and neurological disorders. Most importantly, celiac disease It can occur secretly, without pronounced symptoms, but at the same time cause harm to the body.

Why is genetic testing for celiac disease key?

Diagnosing celiac disease is a complex process, and genetic testing plays an extremely important role in it. It determines the presence of specific genes HLA-DQ2 and HLA-DQ8, which are a prerequisite for the development of this disease. If you do not have these genes, the risk of developing celiac disease is practically zero. This allows you to avoid unnecessary dietary restrictions and further invasive examinations.

Extended genetic marker for celiac disease HLA-DQ2.5, HLA-DQ2.2, HLA-DQ8, HLA-DRB1*04 from Medilab Plus is a modern and accurate way to assess your genetic predisposition to celiac disease. This analysiscovers all major genetic variants associated with the risk of developing the disease.

Who is recommended to undergo an extended genetic marker test for celiac disease?

1. First-degree relatives with patients who have already been diagnosed with celiac disease. If there are cases of celiac disease in your family, your risk increases significantly (up to 10-15%). Even without symptoms, a genetic test can help assess this risk.
2. People with certain autoimmune diseases:
   • Type 1 diabetes: Up to 101% of people with type 1 diabetes also have celiac disease.
   • Autoimmune thyroiditis (Hashimoto's disease, Graves' disease).
   • Sjogren's syndrome.
   • Autoimmune hepatitis.
3. Patients with unexplained clinical conditions that may be related to celiac disease:
   • Chronic iron deficiency anemia of unknown origin.
   • Unexplained osteoporosis or osteopenia (especially in young people).
   • Chronic fatigue, neurological symptoms (ataxia, neuropathy) without an obvious cause.
   • Problems with reproductive function (infertility, repeated miscarriages).
   • Chronic digestive problems (bloating, abdominal pain, changes in stool) for which no other cause has been found.
4. Individuals with genetic syndromes associated with celiac disease: Down syndrome, Turner syndrome, Williams syndrome.
5. Patients with questionable results of serological tests for celiac disease (for example, in IgA deficiency).

Advantages of advanced genetic testing at Medilab Plus:

• High accuracy: Method PCR provides high sensitivity and specificity in detecting genetic markers.
• Does not require dieting: Unlike serological tests and biopsies, genetic testing does not require gluten consumption, allowing you to get tested at any time, even if you are already following a gluten-free diet.
• Definitive exclusion of celiac disease: If test results show the absence of the HLA-DQ2.5, HLA-DQ2.2, HLA-DQ8, and HLA-DRB1*04 genes, celiac disease can be almost completely ruled out as a diagnosis.
• Predictive value: For individuals with positive genetic markers but no symptoms, the test indicates an increased risk of developing celiac disease in the future, allowing for regular monitoring.
• Convenience: A venous blood sample is used for the study.

How to prepare for the analysis?

Special preparation for delivery analysis for genetic markers of celiac disease is not required. You can to take tests at any time, regardless of mealtime or diet.

What do the results mean?

• No HLA-DQ2.5, HLA-DQ2.2, HLA-DQ8, HLA-DRB1*04 genes were detected: The risk of celiac disease is extremely low.
• One or more of these genes have been identified: This indicates a genetic predisposition to celiac disease. In this case, even in the absence of symptoms, further observation is recommended and, if prescribed by a doctor, serological tests (antibodies to tissue transglutaminase IgA, antibodies to deaminated gliadin peptides IgA/IgG) and possibly a biopsy of the small intestine are performed.

It is important to remember that a positive genetic test is not in itself a diagnosis of celiac disease, but it is an important step in the diagnostic workup. It indicates a predisposition and is a basis for further testing.

Take the test on the extended genetic marker of celiac disease HLA-DQ2.5, HLA-DQ2.2, HLA-DQ8, HLA-DRB1*04 in Medilab Plus laboratories and get reliable information about your health. Our specialists are always ready to advise you on the preparation and interpretation of the results. Don't put off taking care of your health for later - get an accurate diagnosis today.