Coagulogram

Coagulogram:

• Prothrombin time (PT)
• Prothrombin index (PTI)
• INR with anticoagulant (INR)
• Activated Partial Thromboplastin Time (APTT)
• Thrombin time
• Fibrinogen (FIB)
• % Quick activity (% Quick)

– Only venous blood is allowed for testing.
– Blood is donated on an empty stomach, after an overnight fast, in the morning.
– Before blood sampling, it is forbidden to drink: tea, coffee, juice, or carbonated drinks.
– 1-2 hours before the blood sampling procedure, you are allowed to drink about 250-300 ml of clean water
– Avoid drinking alcohol and overeating the day before donating blood.
– Exclude fatty, spicy and smoked foods for a day.
– Avoid physical and emotional excitement. Therefore, before the procedure, you should rest for 10-15 minutes to calm down.
– Patients taking hormonal drugs should not violate the dosing schedule on the day of delivery.
– It is advisable to retake the PTI test at the same time.

Coagulogram is a complex comprehensive analysis that includes various laboratory and instrumental methods of research to determine blood coagulation functions. This procedure is important for the diagnosis and control of pathologies associated with blood coagulation, such as hemophilia, thrombosis, bleeding and other diseases.

Blood clotting is an extremely complex process that involves a series of sequential reactions that ensure the formation of a thrombus (clot) that stops blood flow after a vessel is damaged. The main components of this process include plasma clotting factors, platelets, important vitamin K dependencies, extrinsic and intrinsic coagulation, and fibrinolysis (dissolution of blood clots after they have formed).

To determine blood clotting functions, laboratories use various methods that help establish indicators such as clotting time, platelet count, plasma factor levels, and other important parameters. The main methods include:

1. Activated Partial Thromboplastin Time (APTT): This test measures the intrinsic clotting function. It measures the time it takes for a clot to form in the presence of plasma factors.
2. Prothrombin time (PT): This test evaluates extrinsic clotting. It measures the time it takes for a clot to form when plasma factors interact with external substances.
3. Platelet count: Platelets are important for blood clot formation. Too few or too many platelets can lead to bleeding or thrombosis.
4. Determination of clotting factor levels: This test helps detect abnormalities in the levels of specific plasma factors that may affect blood clotting.
5. Fibrinolysis: The study of thrombus dissolution allows us to assess the activity of the fibrinolysis system.

Coagulogram results help doctors diagnose various diseases and pathologies related to the blood clotting system. For example, an elevated APTT may indicate hemophilia, and an elevated PT may indicate problems with extrinsic clotting.

A coagulogram is also important for monitoring the effectiveness of anticoagulant therapy, which is prescribed to patients with thrombosis or at risk of developing it.

In general, a coagulogram is an indispensable tool in the field of hemostasis and hematology, helping to timely detect and treat diseases related to blood clotting and maintain the health of patients.