α-amylase (diastase)

α-amylase (diastase) — is a digestive enzyme that breaks down starch and other complex carbohydrates into simpler compounds. The main sources of amylase in the body are pancreas and salivary glands.

The measurement of α-amylase activity is used to assess the condition of the pancreas and, in certain cases, the salivary glands. The study can be useful for symptoms that may accompany digestive diseases.

What does the analysis show?

Increased or decreased α-amylase activity can be observed in various conditions. In particular, elevated values can occur in acute pancreatitis, exacerbation of certain pancreatic diseases, impaired outflow of pancreatic secretion, as well as in certain diseases of the salivary glands.

It is important to consider that α-amylase level alone does not establish a diagnosis. The result is evaluated together with symptoms, history, and other laboratory and instrumental studies.

When can a doctor order a test?

The analysis may be recommended for:

• acute or recurring pain in the upper abdomen;
• nausea and vomiting, especially with abdominal pain;
• suspected acute or chronic pancreatitis;
• pancreatic dysfunction;
• diseases of the salivary glands;
• the need to monitor laboratory parameters over time.

Biomaterial

For the determination of α-amylase, depending on the purpose, the following can be used: venous blood or urine (diastasis). The specific type of biomaterial depends on the study that is ordered in the laboratory.

Preparation for the study

If the analysis is performed on venous blood, it is usually recommended:

• donate blood in the morning;
• Follow the laboratory's recommendations regarding fasting before the test;
• before delivery, you can drink clean, still water;
• It is advisable to avoid alcohol and excessively fatty foods the day before;
• inform the doctor about medications that are taken regularly.

If investigated urine for diastase, it is necessary to follow the rules for collecting urine established by the laboratory.

The α-amylase result must be evaluated taking into account the reference values of a specific laboratory, as they may vary depending on the research method and type of biomaterial.