Autoimmunology
Antineutrophil cytoplasmic proteinase 3 antibodies (anti-PR3, c-ANCA), IgG
820 UAHAnti-PR3 (c-ANCA) – these are IgG class autoantibodies formed against the enzyme proteinase 3, which is found in neutrophil granules. Their detection is an important diagnostic marker ANCA-associated systemic vasculitis, first of all:
granulomatosis with polyangiitis (Wegener's granulomatosis),
microscopic polyangiitis,
less often - eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).
Anti-PR3 is detected in approximately 80–90% patients with granulomatosis with polyangiitis, therefore, it is one of the most specific laboratory tests for confirming the diagnosis.
Antinuclear antibodies (ANA) / screening
490 UAHAutoimmunology.
Screening:
- RNP-70,
- RNP/Sm,
- Sm,
- SS-B,
- SS-a,
- Scl-70,
- centromere B Jo-1
