Autoimmunology
Antineutrophil cytoplasmic proteinase 3 antibodies (anti-PR3, c-ANCA), IgG
820 UAHAnti-PR3 (c-ANCA) – these are IgG class autoantibodies formed against the enzyme proteinase 3, which is found in neutrophil granules. Their detection is an important diagnostic marker ANCA-associated systemic vasculitis, first of all:
granulomatosis with polyangiitis (Wegener's granulomatosis),
microscopic polyangiitis,
less often - eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).
Anti-PR3 is detected in approximately 80–90% patients with granulomatosis with polyangiitis, therefore, it is one of the most specific laboratory tests for confirming the diagnosis.
Antinuclear antibodies (ANA) / screening
560 UAHAutoimmunology.
Screening:
- RNP-70,
- RNP/Sm,
- Sm,
- SS-B,
- SS-a,
- Scl-70,
- centromere B Jo-1
Antibodies to muscle-specific receptor tyrosine kinase (MuSK)
1,800 UAHAntibodies to MuSK are specific autoantibodies that may be present in patients with myasthenia gravis – an autoimmune disease characterized by skeletal muscle weakness.
Their detection is an important diagnostic criterion, especially in cases where antibodies to acetylcholine receptors (AChR) are absent.
Antibodies to myeloperoxidase (MPO), IgG
600 UAHAnalysis on myeloperoxidase (MPO) antibodies, IgG is an important test to detect and monitor certain systemic vasculitides, which cause inflammation of the blood vessels. Myeloperoxidase is an enzyme in white blood cells, and when the immune system starts to produce antibodies against it, it can be a sign of the disease.
What not to do before taking the test:
To get accurate results, you need to prepare properly for the MPO antibody test, as with most blood tests. Avoid the following:
- Don't eat for 8-12 hours before blood sampling. The analysis is performed strictly on an empty stomach.
- Do not drink alcohol. at least 24 hours before the study.
- Don't smoke. within an hour before analysis.
- Avoid excessive physical and emotional stress. 30 minutes before the procedure.
- Do not take medication. without consulting your doctor. Some medications may affect the results. Be sure to tell your doctor about all medications you are taking.
Antibodies to cyclic citrullinated peptide IgG (Anti-CCP)
550 UAHBiochemical blood tests/Cardio-rheumatic
STD-X autoimmune panel (18 antigens: Ro/SS-A 52, La/ss-B, CENP-B, Scl-70, dsDNA, Jo-1, MPO, PR3, AMA M2, LC 1, LKM 1, PM/Scl 100, SRP 54, Sp 100, gp 210, Ku, Sm, U1-sn RNP))
1,750 UAHAutoimmunology/
Indicators:
- Ro/SS-A 52 (Sjogren's syndrome);
- La/SS-B (Sjogren's syndrome);
- CENP-B (subacute SLE, CREST syndrome, Raynaud's phenomenon, primary biliary cirrhosis);
- Scl 70 (systemic scleroderma);
- dsDNA (systemic lupus erythematosus);
- Jo-1 (polymyositis, dermatomyositis);
- MPO (ANTSA vasculitis, Churg-Strauss syndrome, microscopic polyangiitis);
- PR3 (ANTSA vasculitis, Wegener's granulomatosis);
- AMA M2 (primary biliary cirrhosis);
- LC 1 (autoimmune hepatitis type II);
- LKM 1 (autoimmune hepatitis type II);
- PM/Scl 100 (mixed syndrome: systemic scleroderma/dermatomyositis);
- SRP 54 (dermatopolymyositis, chronic myopathies);
- Sp 100 (primary biliary cirrhosis);
- gp 210 (primary biliary cirrhosis);
- Ku (polymyositis, muscle damage in systemic connective tissue diseases);
- Sm (systemic lupus erythematosus);
- U1-snRNP (systemic connective tissue disease).
Autoimmune Panel: Celiac Disease I
1,000 UAHAutoimmunology/Diagnosis of gastrointestinal diseases/Diagnosis of celiac disease
Indicators:
- IgG to gliadin (Gliadin)
- IgG to tissue transglutaminase (Anti-tTG-IgG)
- Intrinsic Factor — Castle's intrinsic factor
Autoimmune Panel: Celiac Disease II
1,000 UAHAutoimmunology/Diagnosis of gastrointestinal diseases/Diagnosis of celiac disease
Indicators:
- IgA to Gliadin
- IgA to tissue transglutaminase (Anti-tTG-IgA)
- total IgA
